Methods and compositions for screening of human Borna disease vi

Details Methods and compositions for screening of human Borna disease vi Methods and compositions for screening of human Borna disease vi

1997-01-09

2000-05-02

Wortman, Donna

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, C12Q 168, C12Q 170

Patent

active

060570946

ABSTRACT:
Human Borna disease virus (BDV) nucleic acids and polypeptides are described from three psychiatric patients. The human BDV-derived nucleic acids and polypeptides are useful in both DNA- and protein-based assays to detect human BDV in a subject, particularly the detection of BDV nucleic acids, BDV polypeptides and BDV antibodies generated in response to BDV infection.

REFERENCES:
patent: 5654401 (1997-08-01), Clements et al.
patent: 5723293 (1998-03-01), Huang
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De la Torre et al. "Sequence characterization of human borna disease virus". Virus Research. vol. 44, pp 33-44, 1996.
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Richt et al. "Failure to detect borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders". Journal of NeuroVirology. vol. 3, pp 174-18, 1997.
Sauder et al. "Detection of borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence of high sequence conservation of human blood-derived BDV RNA", Journal of Virology. vol. 70, No. 11, pp 7713-7724, Nov. 1996.
De la Torre et al. "Detection of Borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric pateints". Virology. vol. 223, pp 272-282, 1996.
Bode et al. "borna disease virus genome transcribed and expressed in psychiatric patients". Nature Medicine. vol. 1, No. 3, pp 232-236, Mar. 1995.

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