Methods and compositions for screening for presynaptic calcium c

Details Methods and compositions for screening for presynaptic calcium c Methods and compositions for screening for presynaptic calcium c

1995-11-13

2000-07-18

Duffy, Patricia A.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 78, G01N 33566

Patent

active

060906316

ABSTRACT:
Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.

REFERENCES:
patent: 5623051 (1997-04-01), Catterall et al.
Sheng et al, Neuron vol. 13 pp. 1303-1313, Dec. 1994.
Horikawa et al FEBS Letters 330(2) p 236-40 Abstract only, Sep. 13, 1993.
George et al, Macromolecular Sequencing and Synthesis selected methods and applications, pp. 127-149, 1998 Alan R. Liss, Inc.
Bennett et al., "Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones," Science 257:255-259, 1992.
Bennett et al., "The Syntaxin Family of Vesicular Transport Receptors," Cell 74:863-873, 1993.
Leveque et al., "Purification of the N-type Calcium Channel Associated with Syntaxin and Synaptotagmin. A Complex Implicated in Synaptic Vesicle Exocytosis," Journal of Biological Chemistry 269(9): 6306-6312, 1994.
Westenbroek et al., "Biochemical Properties and Subcellular Distribution of an N-type Calcium Channel .alpha.1 Subunit," Neuron 9: 1099-1115, 1992.

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