Methods and compositions for screening for presynaptic calcium c

Details Methods and compositions for screening for presynaptic calcium c Methods and compositions for screening for presynaptic calcium c

1994-11-10

1997-04-22

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

436501, 530350, C07K 1447, C07K 14705, G01N 33566

Patent

active

056230516

ABSTRACT:
Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.

REFERENCES:
Science, vol. 257, Issued 10 Jul. 1992, Bennett et al, "Syntaxin: A Synaptic Protein Implicated in Docking . . . ", pp. 255-259.
Cell, vol. 74, Issued 10 Sep. 1993, Bennett et al, "The Syntaxin Family of Vesicular Transport Receptors", pp. 863-873.
J. Biol. Chem., vol. 269, No. 9, Issued 04 Mar. 1994, Leveque et al, "Purification of the N-type Calcium Channel . . . ", pp. 6306-6312.

Affiliated with

Also associated with

Rating

Methods and compositions for screening for presynaptic calcium c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for screening for presynaptic calcium c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for screening for presynaptic calcium c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-342581