Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-02-21
2006-02-21
Murphy, Joseph (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007800, C435S007900, C435S008000, C435S069100
Reexamination Certificate
active
07001733
ABSTRACT:
The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
REFERENCES:
patent: 5219752 (1993-06-01), Takazawa et al.
patent: 5654150 (1997-08-01), King et al.
patent: 5733731 (1998-03-01), Schatz et al.
patent: 5804387 (1998-09-01), Cormack et al.
patent: 5958707 (1999-09-01), de Vries et al.
patent: 41 26 414 (1993-02-01), None
patent: 92/14836 (1992-09-01), None
patent: WO92/14839 (1992-09-01), None
patent: WO 95/25812 (1995-09-01), None
patent: 96/30515 (1996-10-01), None
patent: WO 96/40721 (1996-12-01), None
Mikita T et al. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol. Oct. 1996;16(10):5811-20.
Cormack et al. FACS-optimized mutants of the green fluorescent protein (GFP). Gene vol. 173 pp. 33-38, 1996.
Ezernieks, J. et al., “The Human IgE Germline Promoter i9s Regulated by Interleukin-4, Interleukin-13, Interferon-α and Interferon-γ Via an Interferon-γ-activated Site and its Flanking Regions,” Eur. J. Biochem., 240:667-673 (1996).
Ferlin, W. et al., “CD40 Signaling Induces Interleukin-4-Independent IgE Switching In Vivo,” Eur. J. Immunol., 26:2911-2915 (1996).
Gauchat, J.F. et al., “Modulation of Il-4 Induced Germline ε RNA Syntheses in Human B Cells by Tumor Necrosis Factor-α, anti-CD40 Monoclonal Antibodies or Transforming Growth Factor-β Correlates with Levels of IgE Production,” International Immunology, 4(3):397-406 (1992).
Loh, R. et al., “Mechanisms of Inhibition of IgE Synthesis by Nedocromil Sodium: Nedocromil Sodium Inhibits Deletional switch Recombination in Human B Cells,” J. Allergy Clin. Immunol., 97(5):1141-1150 (1996).
Vercelli, D. et al., “To E or not to E?,” Int. Arch. Allergy Immunol., 116:1-4 (1998).
Rothman, et al., “Structure and expression of germ line immunoglobin heavy-chain epsilon transcripts: interleukin-r plus lipopolysaccaride-directed switching to C epsilon,”Mol Cell Biol10(4):1672-1679 (Apr. 1990).
Rothman et al., “Identification of a conserved lipopolysaccharaide-plus-interleukin-r-responsive element located at the promoter of germ line epsilon transcripts,”Mol Cell Biol11(11):5551-5561 (Nov. 1991).
Gauchat et al., “Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production,”J Exp Med172(2):463-473 (Aug. 1990).
Qiu et al, “Human IgE mRNA experssion by peripheral blood lymphocytes stimulated with interleukin 4 and pokeweed mitogen,”Eur J Immunol20(10):2191-2199 (Oct. 1990).
Jabara et al., “Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV,”J Immunol. 145(10):3468-73 (Nov. 1990).
Gauchat et al., “Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells,”J Immunol. 148(7):2291-9 (Apr. 1992).
Xu et al., “Replacement of germ-line ε promoter by gene targeting alters control of immunoglobulin heavy chain class switching,”Proc. Natl. Acad. Sci. USA90:3705-3709 (Apr. 1993).
Claassen et al., “Mechanism of pokeweed mitogen inhibition of rhIL-4-induced human IgE synthesis,”Cell Immunol. 140(2):357-69 (Apr. 1992).
Luo et al., “In vitro IgE production by interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by rapamycin,”Clin Immunol Immunopathol62(3):410-420 (Dec. 1991).
Gauchat JF, et al., “Regulation of human IgE synthesis: the role of CD4+ and CD8+ T-cells and the inhibitory effects of interferon-alpha,”Eur Respir J Suppl. 13:31s-38s (Apr. 1991).
Gerondakis S., “Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4,”Proc Natl Acad Sci U S A, 87(4):1581-5 (Feb. 1990).
Armstrong Randall
Ferrick David A.
Fox Bryan
Swift Susan E.
Foley & Hoag LLP
Murphy Joseph
Rigel Pharmaceuticals Inc.
LandOfFree
Methods and compositions for screening for modulations of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for screening for modulations of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for screening for modulations of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3630944