Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-06
2006-06-06
Murphy, Joseph (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007800, C435S007900, C435S008000, C435S069100
Reexamination Certificate
active
07056687
ABSTRACT:
The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more particularly, relates to screening libraries of candidate bioactive agents, for example, nucleic acids and peptides, in cells using an regulatable expression system to enrich for a subpopulation of cells having an altered phenotype due to the presence of a candidate bioactive agent.
REFERENCES:
patent: 5219752 (1993-06-01), Takazawa et al.
patent: 5654150 (1997-08-01), King et al.
patent: 5773731 (1998-06-01), Sakakura et al.
patent: 5804387 (1998-09-01), Cormack et al.
patent: 5834266 (1998-11-01), Crabtree et al.
patent: 5958707 (1999-09-01), de Vries et al.
patent: 6280937 (2001-08-01), Luo et al.
patent: 6455247 (2002-09-01), Nolan et al.
patent: 6465253 (2002-10-01), Wickham et al.
patent: 6613563 (2003-09-01), Sosnowski et al.
patent: 2002/0168649 (2002-11-01), Ferrick et al.
patent: 4126414 (1993-02-01), None
patent: WO 92/14839 (1992-09-01), None
patent: WO 95/25812 (1995-09-01), None
patent: WO 95/25812 (1995-09-01), None
patent: WO 96/30515 (1996-10-01), None
patent: WO 96/38553 (1996-12-01), None
patent: WO 96/40721 (1996-12-01), None
Adam, D., et al. “Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck.”J Biol Chem. Sep. 15, 1993; 268(26):19882-8.
Albrecht, B., et al. “A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation.”Int Immunol. Aug. 1994; 6(8):1143-51.
Allgood, V.E., et al. “Chimeric receptors as gene switches.”Curr Opin Biotechnol. Aug. 1997; 8(4):474-9.
Amara, J.F., et al. “A versatile synthetic dimerizer for the regulation of protein—protein interactions.”Proc Natl Acad Sci USA. Sep. 30, 1997; 94(20):10618-23.
Anders, R.A., et al. “Chimeric granulocyte/macrophage colony-stimulating factor/transforming growth factor-β (TGF-β) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-β signaling.”J Biol Chem. Sep. 6, 1996; 271(36):21758-66.
Bazzoni, F., et al. “Chimeric tumor necrosis factor receptors with constitutive signaling activity.”Proc Natl Acad Sci USA. Jun. 6, 1995; 92(12):5376-80.
Chaplin, P.J., et al. “Production of interleukin-12 as a self-processing 2A polypeptide.”Journal of Interferon and Cytokine Research. 1999; 19:235-41.
Chen, L., et al. “Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.”Cancer Res. Nov. 1, 1997; 57(21):4830-7.
Claassen, J.L., et al. “Mechanism of pokeweed mitogen inhibition of rhIL-4-induced human IgE synthesis.”Cell Immunol. Apr. 1992; 140(2):357-69.
Cormack, B.P., et al. “FACS-optimized mutants of the green fluorescent protein (GFP).” Gene. 1996; 173:33-8.
Declercq, W., et al. “Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: necessity for the 75 kDa-TNF receptor transmembrane domain.”Cytokine. Oct. 1995; 7(7):701-9.
De Felipe, P., et al. “Tricistronic and tetracistronic retroviral vectors for gene transfer.”Human Gene Therapy. Sep. 1, 2000; 11:1921-31.
Desai, D.M., et al. “Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.”Cell. May 7, 1993; 73(3):541-54.
Donnelly, M.L., et al. “Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’.”J Gen Virol. May 2001; 82:1013-25.
Donnelly, M.L., et al. “The cleavage activities of aphthovirus and cardiovirus 2A proteins.”J Gen Virol. Jan. 1997; 78:13-21.
Ezernieks, J., et al. “The human IgE germline promoter is regulated by interleukin-4, interleukin-13, interferon-alpha and interferon-γ via an interferon-γ-activated site and its flanking regions.”Eur J Biochem. Sep. 15, 1996; 240(3):667-73.
Ferlin, W.G., et al. “CD40 signaling induces interleukin-4-independent IgE switching in vivo.”Eur J Immunol. Dec. 1996; 26(12):2911-5.
Fiering, S., et al. “Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.”Genes Dev. Oct. 1990; 4(10):1823-34.
Gauchat, J.F., et al. “Regulation of human IgE synthesis: the role of CD4+ and CD8+ T-cells and the inhibitory effects of interferon-alpha.”Eur Respir J Suppl. Apr. 1991; 13:31s-38s.
Gauchat, J.F., et al. “Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells.”J Immunol. Apr. 1, 1992; 148(7):2291-9.
Gauchat, F.F., et al. “Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.”J Exp Med. Aug. 1, 1990; 172(2):463-73.
Gauchat, J.F., et al. “Modulation of IL-4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production.”Int Immunol. Mar. 1992; 4(3):397-406.
Ichiki, T., et al. “Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element.”J Immunol. Jun. 15, 1993; 150(12):5408-17.
Jabara, H.H., et al. “Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV.”J Immunol. Nov. 15, 1990; 145(10):3468-73.
Jardieu, P. “Anti-IgE therapy.”Curr Opin Immunol. Dec. 1995; 7(6):779-82.
Kawaguchi, Y., et al. “Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines.”Cancer Lett. Jun. 3, 1997; 116(1):53-9.
Kim, D.G., et al. “Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus.”Mol Cell Biol. Aug. 1992; 12(8):3636-43.
Krishnan, K., et al. “Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation.”Oncogene. Jul. 4, 1996; 13(1):125-33.
Kumar, A., et al. “Human BCGF-12kD functions as an autocrine growth factor in transformed B cells.”Eur Cytokine Netw. May-Jun. 1990; 1(2):109-13.
Loh, R.K., et al. “Role of protein tryosine kinases in CD40/interleukin-4-mediated isotype switching to IgE.”J Allergy Clin Immunol. Oct. 1994; 94(4):784-92.
Loh, R.K., et al. “Mechanisms of inhibition of IgE synthesis by nedocromil sodium: nedocromil sodium inhibits deletional switch recombination in human B cells.”J Allergy Clin Immunol. May 1996; 97(5):1141-50.
Luke, G.A., et al. “Translating the message.”Biologist. Apr. 2001; 48(2):79-82.
Luo, H.Y., et al. “In vitro IgE production by Interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by rapamycin.”Clin Immunol Immunopathol. Dec. 1991; 61(3):410-20.
Mares, J., et al. “A chimera between platelet-derived growth factor beta-receptor and fibroblast growth factor receptor-1 stimulates pancreatic beta-cell DNA synthesis in the presence of PDGF-BB.”Growth Factors. 1992; 6(2):93-101.
McBratney, S., et al. “Internal initiation of translation.”Curr Opin Cell Biol. Dec. 1993; 5(6):961-5.
Mikita, T., et al. “Requirements for interleukin-4-induced gene expression and functional characterization of Stat6.”Mol Cell Biol. Oct. 1996; 16(10):5811-20.
Mizuguchi, H., et
Chu Peter
Freiro Annabelle
Hitoshi Yasumichi
Kinsella Todd M.
Liao X. Charlene
Diehl James J.
Francis Carol L.
Keddie James S.
Murphy Joseph
Rigel Pharmaceuticals Inc.
LandOfFree
Methods and compositions for screening for altered cellular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for screening for altered cellular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for screening for altered cellular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3663613