Methods and compositions for regulating nuclear trafficking of p

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 514 12, 530300, 530326, 530350, 530399, A61K 3816, A61K 3818, C07K 1447, C07K 1450

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active

060280581

ABSTRACT:
Methods are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29 kD, is identified as binding to and regulating nuclear localization of FGF-2. Inhibitors of the binding of the 29 kD component and FGF-2 are provided.

REFERENCES:
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