Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-12-11
2007-12-11
Schultz, J. Douglas (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
11122328
ABSTRACT:
Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
REFERENCES:
patent: 2004/0175732 (2004-09-01), Rana
patent: 2005/0059005 (2005-03-01), Tuschl et al.
patent: 2005/0227256 (2005-10-01), Hutvanger et al.
patent: WO 2004076622 (2004-09-01), None
Crooke (2001) in Antisense Drug Technology, Chapt. 1, Basic Principles of Antisense Technology, pp. 1-28 (Springer-Verlag).
Jen et al. (2000) Stem Cells 18:307-319.
Lu et al. (2005) in RNA Interference Technology (Cambridge, Appasani, ed.).
Hutvagner et al. (2004) PloS Biology 2:0465-0475.
Lagos-Quintana et al. (2002) Current Biology 12:735-739, including Supplementary Material, pp. S1-S15.
Meister et al. (2004) RNA 10-544-550.
Tomari and Zamore “Perspective: machines for RNAI,” (2005) Genes & Development 19:517-529.
Bennasser et al. “HIV-1 Encoded Candidate Micro-RNAs and Their Cellular Targets,” (2004) Retrovirology, 1:43.
Doench et al. “siRNAs Can Function as mIRNAs,” (2003) Genes & Development, 17:438-442.
Doench and Sharp “Specificity of MicroRNA Target Selection in Translational Repression,” (2004) Genes & Development, 504-511.
Olsen and Ambros “The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis Elegans by Blocking LIN-14 Protein Synthesis After the Initiation of Translation,” (1999) Developmental Biology, 216:671-680.
Saxena et al. “Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation,” (2003) The Journal of Biological Chemistry, 276(45):44312-44319.
Zeng et al. :MicroRNAs and Small Interfering RNAs Can Inhibit mRNA Expression by Similar Mechanisms, (2003) Proc. Natl. Sci. USA, 100(17):9779-9784,
Lagos-Quintana et al. “Identification of Tissue-Specific MicroRNAs from Mouse,” (2002) Current Biology, 12:736-739.
Sempere et al. “Expression Profiling of Mammalian MicroRNAs Uncovers A Subset of Brain-Expressed MicroRNAs with Possible Roles In Murine and Human Neuronal Differentiation,” (2004) Genome Biology 5:3:R13.
Friebe et al. “Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replicaiton,” (2001) Journal of Virology, 75(24):12047-12057.
Sunkar and Zhu “Novel and Stress-Regulated MicroRNAs and Other Small RNAs from Arabidopsis,” (2004) The Plant Cell, 16:2001-2019.
Kassachau et al. “P1/HC-Pro, A Viral Suppressor of RNA Silencing, Interferes with Arabidopsis Development and miRNA Function,” Developmental Cell (2003) 4:205-217.
Cullen “Derivation and Function of Small Interfering RNAs and MircoRNAs,” Virus Research (2004) 102:3-9.
Boutla et al. “Developmental Defects by Antisense-Mediated Inactivation of Micro-RNAs 2 and 13 In Drosphilia and the Identification of Putative Target Genes,” Nucleic Acids Research (2003) 31(17):4973-4980.
Baskerville and Bartel “Microarray Profiling of MicroRNAs Reveals Frequent Coexpression with Neighboring miRNAs and Host Genes,” (2005) RNA, 11:241-247.
Chen “A MicroRNA as A Translational Repressor of APETALA2 in Arabidopsis Flower Development,” (2004) SCIENCE, 303:2022-2025.
Hutvagner and Zamore “A MicroRNA in A Multiple-Turnover RNAI Enzyme Complex,” (2002) SCIENCE, 297:2056-2060.
John et al. “Human MicroRNA Targets,” (2004) PLoS Biology, 2(11):1862-1879.
Ikeda et al. “Selectable Subgenomic and Genome-Length Dicistronic RNAs Derived from an Infectious Molecular Clone of the HCV-N Strain of Hepatitis C Virus Replicate Efficiently in Cultured Huh7 Cells,” (2002) Journal of Virology, 76(6):2997-3006.
Lewis et al. “Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets,” (2005) Cell, 120:15-20.
Lewis et al, “Prediction of Mammalian MicroRNA Targets,” (2003) Cell, 115:787-798,
Lim et al. “Microarray Analysis Shows that Some MicroRNAs Downregulated Large Numbers of Target mRNAs,” (2005) Nature, 433:769-773.
Pfeffer et al. “Identification of Virus-Encoded MicroRNAs,” (2004) SCIENCE, 304:734-736.
Taylor et al. “Hepatitis Delta Virus Replication and Liver Disease,” (2004) RNA Biology 1:106.
Yetka et al. “MicroRNA-Directed Cleavage of HOXB8 mRNA,” (2004) SCIENCE, 304:594-596.
Jopling Catherine L.
Lancaster Alissa M.
Sarnow Peter
Casimir Jones S.C.
Schultz J. Douglas
The Board of Trustees of the Leland Stanford University
Wollenberger Louis
LandOfFree
Methods and compositions for reducing viral genome amounts... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for reducing viral genome amounts..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for reducing viral genome amounts... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3892197