Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-07-11
2000-10-24
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424486, 424497, 424444, 424426, 424 7817, A61B 1900
Patent
active
061363332
ABSTRACT:
The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
REFERENCES:
patent: 3890253 (1975-06-01), Takeshita et al.
patent: 3912692 (1975-10-01), Casey et al.
patent: 3997512 (1976-12-01), Casey et al.
patent: 4048256 (1977-09-01), Casey et al.
patent: 4095600 (1978-06-01), Casey et al.
patent: 4118470 (1978-10-01), Casey et al.
patent: 4122129 (1978-10-01), Casey et al.
patent: 4343931 (1982-08-01), Barrows
patent: 4346709 (1982-08-01), Schmitt
patent: 4429080 (1984-01-01), Casey et al.
patent: 4438253 (1984-03-01), Casey et al.
patent: 4452973 (1984-06-01), Casey et al.
patent: 4529792 (1985-07-01), Barrows
patent: 4661530 (1987-04-01), Gogolewski et al.
patent: 4705820 (1987-11-01), Wang et al.
patent: 4716203 (1987-12-01), Casey et al.
patent: 4781183 (1988-11-01), Casey et al.
patent: 4788979 (1988-12-01), Jarrett et al.
patent: 4791929 (1988-12-01), Jarrett et al.
patent: 4826945 (1989-05-01), Cohn et al.
patent: 4842851 (1989-06-01), Grollier et al.
patent: 4857602 (1989-08-01), Casey et al.
patent: 4877539 (1989-10-01), Ploog et al.
patent: 4882168 (1989-11-01), Casey et al.
patent: 4911926 (1990-03-01), Henry et al.
patent: 4937254 (1990-06-01), Sheffield et al.
patent: 4988777 (1991-01-01), Hergenrother et al.
patent: 5075115 (1991-12-01), Brine
patent: 5080665 (1992-01-01), Jarrett et al.
patent: 5093351 (1992-03-01), Batt
patent: 5100992 (1992-03-01), Cohn et al.
patent: 5133755 (1992-07-01), Brekke
patent: 5202413 (1993-04-01), Spinu
patent: 5278255 (1994-01-01), Weaver, Jr. et al.
patent: 5288496 (1994-02-01), Lewis
patent: 5314969 (1994-05-01), Imaizumi et al.
patent: 5380536 (1995-01-01), Hubbell et al.
patent: 5380813 (1995-01-01), Seppala et al.
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5447966 (1995-09-01), Hermes et al.
Wiseman, "Polymers for the Prevention of Surgical Adhesions"; Polymeric Site-specific Pharmacotherapy, pp. 369-421, A.J. Domb, ed., John Wiley & Sons, 1994.
DiZerega and Rodgers, "The Peritoneum", ch. 9-10, pp. 369-420, Springer-Verlag, 1994.
Sawhney et al., "Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) Diacrylate Macromers"; Macromolecules, 26(4):581-587, 1993.
West and Hubbell, "Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model"; Biomaterials, 16(15):1153-1156, 1995.
Sawhney et al., "Prevention of Postoperative Peritoneal Adhesions Using In Situ Photopolymerization of Novel Biodegradable Hydrogels"; pre-publication copy submitted to Fertility and Sterility, 1992.
Hill-West et al., "Prevention of Postoperative Adhesions in the Rat by In Situ Photopolymerization of Bioresorbable Hydrogel Barriers"; Obstetrics & Gynecology, 83(1): 59-64, 1991.
Sawhney et al., "Optimization of Photopolymerized Bioerodible Hydrogel Properties for Adhesion Prevention"; Journal of Biomedical Materials Research, 28: 831-838, 1994.
Sawhney et al., "Bioerodible Hydrogels Based on Photopolymerized Poly (ethyleneglycol)-co-poly (.alpha.-hydroxy acid) Diacrylate Macromers"; American Chemical Society, 26(4): 581-587, 1993.
Cohn Daniel
Hotovely Anna
Pines Eli
Coleman Henry D.
Life Medical Sciences, Inc.
Sudol R. Weil
Webman Edward J.
LandOfFree
Methods and compositions for reducing or eliminating post-surgic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for reducing or eliminating post-surgic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for reducing or eliminating post-surgic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960703