Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-19
1997-10-28
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 34, 514 35, 514183, 514283, 514411, 514506, 514515, 514765, 514950, 424498, A61K 3125, A61K 31765, A61K 31785, A61K 4710
Patent
active
056818122
ABSTRACT:
The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.
REFERENCES:
Paradis, R. et al., "Use of pluronic micelles to overcome multidrug resistance," International Journal of Oncology, 5:1305-1308 (1994).
Page, M. et al., "Elimination of P-170 Mediated Multi-Drug Resistance by Solubilization in Pluronic Micelles," Database BIOSIS, Philadelphia, PA, (1992) and Proc. Am. Assoc. Cancer Res. Ann. Meet., 33: 552 (1992).
Buckingham, L.E. et al., "Comparison of Solutol HS 15, Cremophor EL and novel ethoxylated fatty acid surfactants and multidrug resistance modification agents," Int. J. Cancer, 62(4):436-442 (1995).
Chong, A.S. et al. "Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells," Cancer Immunol. Immunother., 36(2):133-139 (1993).
Coon, et al., "SOLUTOL.RTM. HS15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverse multi-drug resistance," Cancer Research, vol. 51, pp. 897-902 (Feb. 1991).
Coon, J.S., et al., "Survey of surfactants for reversing multidrug resistance," Proc. Am. Assoc. Cancer Res. Annu. Meet., vol. 33, p. 484 (Mar. 1992).
Balasubramanian Mannarsamy
Coon John S.
Emanuele R. Martin
Shah Himanshu
Nutter Nathan M.
Rush Presbyterian-St. Luke's Medical Center
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