Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1997-10-07
2000-05-30
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 6, 435 71, 435 691, 536 231, C12Q 168, G01N 3353
Patent
active
060689722
ABSTRACT:
The invention relates to methods and compositions for manipulating bacterial resistance to non-antibiotic antibacterial compositions, disinfectants and organic solvents. The invention provides methods for rendering bacterial cells susceptible to non-antibiotic antibacterial compositions. Also provided are methods to reduce the selection of bacterial mutants having an multiple antibiotic resistance phenotype by non-antibiotic antibacterial compositions. The invention also provides methods for testing the ability of non-antibiotic antibacterial compositions to select for or induce a multiple antibiotic resistance phenotype in bacteria. Also provided are methods for increasing or decreasing bacterial tolerance to organic solvents by increasing or decreasing the activity of bacterial organic solvent efflux pumps. Compositions useful in the foregoing methods are also provided.
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Brusca John S.
Garry Sean M
Hanley, Esq. Elizabeth A.
Trustees of Tufts College
Williams Megan E.
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