Methods and compositions for providing articles having improved

Details Methods and compositions for providing articles having improved Methods and compositions for providing articles having improved

1990-12-24

1992-03-24

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carbohydrate or derivative as a reactant

527314, 527315, 523112, 514822, 604 96, 604403, 606228, 623 11, C08G 8300, A01N 100

Patent

active

050989774

ABSTRACT:
Improved articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their preparation and use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extension of 12 to 22 carbon atoms. When exposed to blood, the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation as well as other biocompatibility parameters, such as foreign body immune responses.

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