Methods and compositions for production of mycoplasmal adhesins

Details Methods and compositions for production of mycoplasmal adhesins Methods and compositions for production of mycoplasmal adhesins

1987-11-10

1991-06-25

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 711, 435 91, 4351721, 4351723, 4352523, 4353201, 536 27, 935 6, 935 8, 935 9, 935 12, 935 22, 935 29, 935 59, 935 60, 935 72, 935 77, 935 79, C12Q 168, C12N 121, C12N 1531

Patent

active

050266365

ABSTRACT:
The molecular cloning and nucleotide sequence of the complete structural gene encoding Mycoplasma pneumoniae P1 cytadhesin and the amino acid sequence of the P1 protein is described. The present invention provides recombinant DNA clones encoding the complete P1 protein as well as clones expressing P1 polypeptides with cytadhesin epitopes. The substantially purified nucleic acid molecular recombinant vectors, recombinant cells, and recombinant polypeptides of the present invention are useful as hybridization probes and immunodiagnostic reagents and may be used to prepare anti-mycoplasmal vaccines.

REFERENCES:
Manicitis et al., 1982, Molecular Cloning, p.n-x, Cold Spring Harbor Laboratory.
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Henikoff, Elsevier Science Publishers, 28:351-359 (1984).
Leith and Baseman, Journal of Bacteriology, 157:678-680 (1984).
Baseman et al., Molecular Basis of Oral Microbial Adhesin, Ed. Mergenhagen, pp. 18-23 (1985).
Morrison-Plummer et al., Journal of Immunological Methods, 64:165-178 (1983).
Krause and Baseman, Infect. Immun., 39:1180-1186 (1983).
Krause et al., Infect. Immun., 39:830-836 (1983).
Leith et al., Journal of Experimental Medicine, 157:502-504 (1983).
Krause et al., Infect. Immun., 35:809-817 (1982).
Baseman et al., Journal of Bacteriology, 151:1514-1522 (1982).
Messing et al., Nucleic Acids Research, 9:309-321 (1981).

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