Methods and compositions for production of mycoplasmal adhesins

Details Methods and compositions for production of mycoplasmal adhesins Methods and compositions for production of mycoplasmal adhesins

1991-03-05

1994-01-25

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530327, 530350, 530395, 530825, 530808, C07K 708, C07K 700, C07K 1300

Patent

active

052816940

ABSTRACT:
The molecular cloning and nucleotide sequence of the complete structural gene encoding Mycoplasma pneumoniae P1 cytadhesin and the amino acid sequence of the protein is described. The present invention provides recombinant DNA clones encoding the complete P1 protein as well as clones expressing P1 polypeptides with cytadhesin epitopes. The substantially purified nucleic acid molecules, recombinant vectors, recombinant cells, and recombinant polypeptides of the present invention are useful as hybridization probes and immunodiagnostic reagents and may be used to prepare anti-mycoplasmal vaccines.

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Leith and Baseman; Journal of Bacteriology 157:678-680 (1984).
Baseman et al.; Molecular Basis of Oral Microbial Adhesin, Ed. Megenhagen, pp. 18-23 (1985).
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Krause and Baseman; Infect. Immun. 39:1180-1186 (1983).
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Young and Davis; Proc. Natl. Acad. Sci. USA 80:1194-1198 (Mar. 1983).
Young and Davis; Science 222:778-782 (Nov. 1983).
Maniatis et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory (1982).

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