Methods and compositions for preventing secondary cataracts

Details Methods and compositions for preventing secondary cataracts Methods and compositions for preventing secondary cataracts

1990-05-01

1997-04-01

Green, Randall L.

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

514912, A61M 3100

Patent

active

056161220

ABSTRACT:
Novel methods and compositions are provided for preventing secondary cataracts. A cytotoxic agent is employed which is introduced into the anterior chamber of the eye to inhibit proliferation of remnant tens epithelial cells after extracapsular cataract extraction. Desirably a non-cytotoxic agent crossreactive with the cytotoxic agent is introduced prior to introduction of the cytotoxic agent. The agents can be provided as kits.

REFERENCES:
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4432751 (1984-02-01), Emery et al.
patent: 4590071 (1981-05-01), Scannon et al.
patent: 4698420 (1985-02-01), Urnovitz
patent: 4871350 (1989-10-01), Lam et al.
patent: 4909784 (1990-03-01), Dubroff
"Use of Immunotoxin to Inhibit Proliferating Human Corneal Endothelium" by Fulcher et al. Investigative Ophthalmology & Visual Science (1988).
"Methotrexate-Anticollagen Conjugate Inhibits In Vitro Lens Cell Outgrowth" by Hansen et al., Investigative Ophthalmology & Visual Science (1987) 28:1206-1209.
"Use of Immunotoxin to Inhibit Proliferating Human Corneal Endothelium" by Fulcher et al. Investigative Ophthalmology & Visual Science (1988) 29:755-759.

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