Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Patent
1995-06-06
1999-01-12
Lankford, Jr., Leon B.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
424 9321, 424 937, 424444, 435325, 435366, 435178, 536 20, 536 552, A01N 6300, C08B 3708, C07H 504, C12N 500
Patent
active
058583505
ABSTRACT:
The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
REFERENCES:
patent: 3988411 (1976-10-01), Capozza
patent: 3989535 (1976-11-01), Capozza
patent: 4749620 (1988-06-01), Rha et al.
patent: 4803168 (1989-02-01), Jarvis, Jr.
patent: 4942129 (1990-07-01), Goosen et al.
patent: 5071977 (1991-12-01), Cassels et al.
patent: 5116747 (1992-05-01), Moo-Young et al.
patent: 5219749 (1993-06-01), Bouriotis et al.
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5573934 (1996-11-01), Hubbell et al.
Berkeley, R.C.W. et al. (ed.), Microbial Polysaccharides and Polysaccharases, Academic Press, pp. 205-216, 1979.
Zielinski and Aebischer, 1994, "Chitosan as a matrix for mammalian cell encapsulation", Biomaterials 15(13):1049-1056.
Vournakis et al., 1994, "Isolation & characterization of pure poly-N-acetylglucsoamine: Controlled enzymatic deacetylation and formulation for tissue engineering applications", J Cell Biochem Suppl O, No. 18C, p. 283 Abstract PZ 313, Keystone Symposium on Tissue Engineering.
Polk, A. et al., 1994, J. of Pharmaceutical Sciences, 83(2):178-185.
Matthew et al., 1993, "Complex coacervate microcapsules for mammalian cell culture and artificial organ development", BioTechnol Prog 9(5):510-519.
Groboillot et al., 1993, "Membrane formation by interfacial cross-linking of chitosan for microencapsulation of Lactococcus lactis", Biotechnology and Bioengineering 42(10):1157-1163.
Aebisher, P. et al., 1993, in "Fundamentals of Animal Cell Encapsulation and Immobilization", CRC Press, pp. 197-224.
Mireles, C. et al., 1992, in "Advances in Chitin and Chitosan", Brine, C.J. et al., eds., Elsevier Publishers, Ltd., pp. 506-515.
Thanoo et al., 1992, "Cross-linked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals", J. Pharm. Pharmacol., 44, 283-286.
Dong, C. and Rogers, J.A., 1991, Journal of Controlled Release, 17:217-224.
US Pharmacopeia XXII, 1991, Supplement 5, pp. 2702-2703.
Yoshioke, T. et al., 1990, Biotechnol Bioeng. 35:66-72.
Kurita, K. et al., 1990, "Preparations of soluble chitin derivatives and the modifications to branched chitins" Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.) 31:624-625.
US Pharmacopeia XXII, 1990, pp. 1415-1497.
US Pharmacopeia XXII, 1990, 1497-1500.
Kurita, K. and Inoue, S., 1989, in "Chitin and Chitosan", Skjak-Braek et al., Elsevier Science Publishing Co., Inc., pp. 365-372.
Bedemeier et al., 1989, Pharm. res., 6(5), 413-417.
Hirano, S., 1989, "Production and application of chitin and chitosan in Japan," in Chitin and Chitosan, Skjak-Braek, Anthonsen, and Sanford, eds. Elsevier Science Publishing Co., pp. 37-43.
Maresh, G. et al., 1989, "Hydroxypropylation of chitosan," in Chitin and Chitosan, Skjak-Braek, Anthonsen, and Sanford, eds. Elsevier Science Publishing Co., pp. 389-395.
Blackwell, 1988, Meth. Enz., 161, 435-442.
Austin, P.R. and Sennett, S., 1986, "Dry chitosan salts and complexes of aliphatic carboxylic acids," in Chitin in Nature and Technology, Muzzarelli et al., Plenum Press, New York, pp. 279-286.
Komai, T. et al., 1986, "Biomedical evaluation of acylated chitins as coating materials," in Chitin in Nature and Technology, Muzzarelli et al., eds. Plenum Press, New York, pp. 497-506.
Nishi, N. et al., 1986, "Preparation and characterization of phosphorylated chitin and chitosan," in Chitin in Nature and Technology, Muzzarelli et al., eds. Plenum Press, New York, pp. 297-299.
Domard, A., 1986, "Circular dichroism study on N-acetylglucosamine oligomers," Int. J. Macromol. 8:243-246.
Staros, J.V., et al., 1986, "Enhancement by N-hydroxysulfosuccinate of water soluble carbodiimide mediated coupling reactions," Anal. Biochem. 156:220-222.
Hwang, C. et al., 1985, "Encapsulation with Chitosan: Transmembrane Diffusion of Proteins in Capsules," in Muzzarelli, R. et al., eds., Chitin in Nature and Technology, Plenum Press, pp. 389-396.
Vahouny, G.V., 1983, Journal of Clinical Nutrition, 38:278-284.
Tokura, S. et al., 1983, "Studies on chitin VIII. Some properties of water soluble chitin derivatives," Polym. J. 15:485-489.
Davis, M. and Preston, J.F., 1981, "A simple modified carbodiimide method for conjugation of small molecular weight compounds to immunoglobulin G with minimal protein crosslinking," Anal. Biochem. 116:402-407.
Hirano, S. et al., 1981, "SEM ultrastructure studies of N-acyl- and N-benzylidene-chitosan membranes," J. Biomed. Mat. Res. 15:903-911.
Hirano, S. et al., 1976, "Selective N-acylation of chitosan," Carbohydrate Research 47:315-320.
Schweiger, RG., 1972, "Polysaccharide sulfates I. Cellulose sulfate with a high degree of substitution," Carbohydrates Res. 21:219-228.
Noguchi, J. et al., 1969, "Chitosan epichlorohydrin anion exchange resin with primary amine as absorption site," Kogyo Kagaku Zasshi 72:796-799.
Blackwell et al., 1967, J. Mol. Biol., 28, 383-385.
Falk et al., 1966, "Studies on chitin (.beta.-(1.fwdarw.4)-linked 2-acetamido-2-deoxy-D-glucan) fibers of the diatom thalassiosira fluviatilis hustedt", Can. J. Chem., 44, 2269-2281.
McLachlan and Craigne, 1966, Some Contemp. Stud. Mar. Sci., 511-517.
McLachlan, A.G. et al, 1965, "Studies on the chitin (chitin: poly-N-acetylglucosamine) fibers of the diatom thalassiosira fluviatilis hustedt," Can. J. Botany 43:707-713.
Schorigin, P. and Hait, E., 1934, Chem. Ber. 67:1712-1714.
Finkielsztein Sergio
Helton Mike
Pariser Ernest R.
Vournakis John N.
Lankford , Jr. Leon B.
Marine Polymer Technologies
Tate Christopher R.
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