Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-06
1997-06-03
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 2, 514 8, 514 62, 536 20, 536 552, A61K 3173, C08B 3708
Patent
active
056354932
ABSTRACT:
The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
REFERENCES:
patent: 3988411 (1976-10-01), Capozza
patent: 3989535 (1976-11-01), Capozza
patent: 4378017 (1983-03-01), Kosugi et al.
patent: 4532134 (1985-07-01), Malette et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 5008116 (1991-04-01), Cahn
patent: 5071977 (1991-12-01), Cassels et al.
patent: 5219749 (1993-06-01), Bouriotis et al.
patent: 5229123 (1993-07-01), Masubuchi et al.
US Pharmacopeia XXII, 1991, Supplement 5, pp. 2702-2703.
Kurita, K. et al., 1990, "Preparation of soluble chitin derivatives and the modifications to branched chitins" Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.) 31:624-625.
US Pharmacopeia XXII, 1990, pp. 1415-1500.
Hirano, S., 1989, "Production and application of chitin and chitosan in Japan,"in Chitin and Chitosan, Skjak-Braek, Anthonsen, and Sanford, eds. Elsevier Science Publishing Co., pp. 37-43.
Maresh, G. et al., 1989, "Hydroxypropylation of chtiosan," in Chitin and Chitosan, Skjak-Braek, Anthonsen, and Sanford, eds. Elsevier Science Publishing Co., pp. 389-395.
Austin, P.R. and Sennett, S., 1986, "Dry chitosan salts and complexes of aliphatic carboxylic acids," in Chitin in Nature and Technology, Muzzarelli et al., eds. Plenum Press, New York, pp. 279-286.
Komai, T. et al., 1986, "Biomedical evaluation of acylated chitins as coating materials," in Chitin in Nature and Technology, Muzzarelli et al., eds. Plenum Press, New York, pp. 497-506.
Nishi, N. et al., 1986, "Preparation and characterization of phosphorylated chitin and chitosan," in Chitin in Nature and Technology, Muzzarelli et al., eds. Plenum Press, New York, pp. 297-299.
Domard, A., 1986, "Circular dichroism study on N-acetylglucosamine oligomers," Int. J. Macromol. 8:243-246.
Tokura, S. et al., 1983, "Studies on chitin VIII. Some properties of water soluble chitin derivatives," Polym. J. 15:485-489.
Davis, M. and Preston, J.F., 1981, "A simple modified carbodiimide method for conjugation of small molecular weight compounds to immunoglobulin G with minimal protein crosslinking," Anal. Biochem. 116:402-407.
Hirono, S. et al., 1981, "SEM ultrastructure studies of N-acyl-and N-benzylidene-chitosan membranes," J. Biomed. Mat. Res. 15:903-911.
Hirano, S. et al., 1976, "Selective N-acylation of chitosan," Carbohydrate Research 47:315-320.
Schweiger, RG., 1972, "Polysaccharide sulfates I. Cellulose sulfate with a high degree of substitution," Carbohydrate Res. 21:219-228.
Noguchi, J. et al., 1969, "Chitosan epichlorohydrin anion exchange resin with primary amine as absorption site," Kogyo Kagaku Zasshi 72:796-799.
McLachlan, A.G. et al, 1965, "Studies on the chitin (chitin: poly-N-acetylglucosamine) fibers of the diatom thalassiosira fluviatilis hustedt," Can. J. Botany 43:707-713.
Schorigin, P. and Hait, E., 1934, Chem. Ber. 67:1712-1714.
Falk et al. Can. J. Chem. 1966, 44, 2269-2281.
McLachlan and Craigie Some Contemp. Stud. Mar. Sci. 1966, 511-517.
Bodemeier et al. Pharm. Res. 1989, 6(5), 413-417.
Blackwell Meth. Enz. 1988, 161, 435-442.
Blackwell et al. J. Mol. Biol. 1967, 28, 383-385.
Thanoo et al. J. Pharm. Pharmacol. 1992, 44, 283-286.
Hirano et al., 1990, "The Regulation of Serum Cholesterol Level by Oral Administration of Chitosan in Rabbits," in Proceedings of The International Symposium on Chitin Derivatives in Life Sciences, Oct. 5-7., pp. 115-120.
Zielinski and Aebischer, 1994, "Chitosan as a matrix for mammalian cell encapsulation", Biomaterials 15(13): 1049-1056.
Vournakis et al., 1994, "Isolation & characterization of pure poly-N-acetylglucosamine: Controlled enzymatic deacetylation and formulation for tissue engineering applications", J Cell Biochem Suppl ), No. 18C, p. 283 Abstract PZ 313, Keystone Symposium on Tissue Engineering.
Polk, A. et al., 1994, J. of Pharmaceutical Sciences, 83(2):178-185.
Matthew et al., 1993, "Complex coacervate microcapsules for mammalian cell culture and artificial organ development", Biotechnol Prog 9(5):510-519.
Groboillot et al., 1993, "Membrane formation by interfacial cross-linking of chitosan for microencapsulation of Lactococcus lactis" Biotechnology and Bioengineering 42(10):1157-1163.
Aebisher, P. et al., 1993, in "Fundamentals of Animal Cell Encapsulation and Immobilization", CRC Press, pp. 197-224.
Mireles, C. et al., 1992, in "Advances in Chitin and Chitosan", Brine, C.J. et al., eds., Elsevier Publishers, Ltd., pp. 506-515.
Thanoo et al., 1992, "Cross-linked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals", J. Pharm. Pharmacol., 44, 283-286.
Dong, C. and Rogers, J.A., 1991, Journal of Controlled Release, 17:217-224.
Yoshioke, T. et al., 1990, Biotechnol Bioeng. 35:66-72.
Kurita, K. et al., 1990, "Preparations of soluble chitin derivatives and the modifications to branched chitins" Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.) 31:624-625.
Kurita, K. and Inoue, S., 1989, in "Chitin and Chitosan", Skjak-Braek et al., eds., Elsevier Science Publishing Co., Inc., pp. 365-372.
Bedemeier et al., 1989, Pharm. res., 6(5), 413-417.
Blackwell, 1988, Meth. Enz., 161, 435-442.
Staros, J.V., et al., 1986, "Enhancement by N-hydroxysulfosuccinate of water soluble carbodiimide mediated coupling reactions" Anal. Biochem. 156:220-222.
Hwang, C. et al., 1985, "Encapsulation with Chitosan: Transmembrane Diffusion of Proteins in Capsules," in Muzzarelli, R. et al., eds., Chitin in Nature and Technology, Plenum Press, pp. 389-396.
Vahouny, G.V., 1983, Journal of Clinical Nutrition, 38:278-284.
Blackwell et al., 1967, J. Mol. Biol., 28, 383-385.
Falk et al., 1966, "Studies on chitin (.beta.-(1.fwdarw.4)-linked 2-acetamido-2-deoxy-D-glucan) fibers of the diatom thalassiosira fluviatilis hustedt", Can. J. Chem., 44, 2269-2281.
McLachlan and Craigie 1966, Some Contemp. Stud. Mar. Sci., 511-517.
McLachlan, A.G. et al, 1965, "Studies on the chitin (chitin:poly-N-acetylglucosamine) fibers of the diatom thalassiosira fluviatilis hustedt," Can. J. Botany 43:707-713.
Finkielsztein Sergio
Helton Mike
Pariser Ernest R.
Vournakis John N.
Fonda Kathleen Kahler
Kight John
Marine Polymer Technologies Inc.
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