Methods and compositions for plasma and organ imaging

Details Methods and compositions for plasma and organ imaging Methods and compositions for plasma and organ imaging

1983-10-04

1986-08-19

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

540590, 424 9, A61K 4300, A61K 4900

Patent

active

046069089

ABSTRACT:
Halogenated dibenzazepines, particularly flouro- or iododesmethylimipramine, find use for measuring regional blood flows and for retention in particular organs for radioactive imaging. Such compositions are introduced into the arterial flow leading to the organ, and the compositions bind to the organ as a result of interaction with cellular receptors. The compositions have been found to display very high retention rates in the organ for relatively long periods of time.

REFERENCES:
patent: 4124583 (1978-11-01), Georgiev et al.
patent: 4495281 (1985-01-01), Buckler et al.
Lee et al., Synthesis and Applications of Isotopically Labeled Compounds, Proceedings of an International Symposium, Kansas City, MO, U.S.A., 6-11 Jun. 1982, W. P. Duncan et al, eds., 203-204.
Preskoen et al., J. Pharmacol. Exp. Therapeut., 213 (2) 313-20, (1980).
Fed. Proc. (1983) 42: "Intraorgan Regional Plasma Flows Using Highly Extracted Solute Desmethylimipramine", Little et al.

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