Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1998-05-01
2000-01-18
Woodward, Michael P.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
514 13, 514 14, 514 15, 514 16, 514 17, 514 12, 530324, 530325, 530326, 530327, 530329, 530333, 530335, 530338, A61K 3800, C07K 500
Patent
active
060158816
ABSTRACT:
The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.
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Bray Brian
Kang Myung-Chol
Lichty Maynard
Mader Catherine
Merutka Gene
Gupta Anish
Trimeris, Inc.
Woodward Michael P.
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