Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Patent
1996-01-24
1997-10-28
Loring, Susan A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
4241301, 4241411, 4241501, 4241631, 4241651, 4241691, 4241701, 5303871, 5303881, 5303882, 5303884, 5303891, 5303895, A61K 3940, A61K 39085, A61K 3909, A61K 39104
Patent
active
056815654
ABSTRACT:
The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.
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Giridhar Girish
Gristina Anthony G.
Loring Susan A.
Medical Sciences Research Institute
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