Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2008-05-20
2008-05-20
Romeo, David (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S130100, C424S139100, C435S377000
Reexamination Certificate
active
10847972
ABSTRACT:
Methods and compositions for modulating growth of a neuron with a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway are disclosed. Also disclosed are methods for identifying a substance that modulates growth of a neuron by obtaining a candidate substance and contacting the candidate substance with the neuron are disclosed and methods for modulating growth of a neuron in a subject using a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway. The Wnt, Wnt-like substance, and/or chemical compounds affecting a Wnt signaling pathway can be delivered to the subject using gene therapy techniques. Also disclosed are pharmaceutical compositions for modulating growth of a neuron in a mammal that include a Wnt or a Wnt-like substance. Methods and compositions for inhibiting growth of a neuron are also disclosed.
REFERENCES:
patent: 4554101 (1985-11-01), Hopp
patent: 4797368 (1989-01-01), Carter et al.
patent: 5139941 (1992-08-01), Muzyczka et al.
patent: WO 99/57248 (1999-11-01), None
patent: WO 01/74856 (2001-10-01), None
patent: WO01/88103 (2001-11-01), None
patent: WO02/063959 (2002-08-01), None
Keeble et al., The International Journal of Biochemistry & Cell Biology, vol. 38, Issue 12, 2006, pp. 2011-2017.
Aksentijevich, I. et al., “In Vitro and In Vivo Liposome-Mediated Gene Transfer Leads to HumanMDR1Expression in Mouse Bone Marrow Progenitor Cells”Hum. Gene Ther.(1996) 7:1111-1122.
Altman, J. and Bayer, S.,The Development of the Rat Spinal Cord,Springer-Verlag, Berlin-Heidelberg-New York-Tokyo (1984) 85:1-164 (Cover and Table of Contents).
Augsburger, A. et al., “BMPs as Mediators of Roof Plate Repulsion of Commissural Neurons,”Neuron(1999) 24:127-141.
Borello, U. et al., “Differential expression of the Wnt putative receptorsFrizzledduring mouse somitogenesis,”Mech. Dev.(1999) 89:173-177.
Boussif, O. et al., “A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine,”Proc. Natl. Acad. Sci. USA(1995) 92:7297-7301.
Bradley, R.S. and Brown, A.M.C., “The proto-oncogeneint-1 encodes a secreted protein associated with the extracellular matrix,”EMBO J.(1990) 9(5):1569-1575.
Bueno, D. and Heath, J.K., “Co-expression pattern analysis ofFgf4, Fgf8andShhgene expression at diverse signalling centers during mouse development,”Int. J. Dev. Biol. Suppl.(1996) 1:79S-80S.
Caley, I.J. et al., “Humoral, Mucosal, and Cellular Immunity in Response to a Human Immunodeficiency Virus Type 1 Immunogen Expressed by a Venezuelan Equine Encephalitis Virus Vaccine Vector,”J. Virology(1997) 71(4):3031-3038.
Carbonelli, D.L., et al., “A plasmid vector for isolation of strong promoters inEscherichia coli,” FEMS Microbiol. Lett.(1999) 177:75-82.
Chen, C. and Okayama, H., “High-Efficiency Transformation of Mammalian Cells by Plasmid DNA,”Mol. Cell Biol.(1987) 7(8):2745-2752.
Christiansen, J.H. et al., “MurineWnt-11 andWnt-12 have temporally and spatially restricted expression patterns during embryonic development,”Mech. Dev.(1995) 51:341-350.
Cocea, L., “Duplication of a region in the multiple cloning site of a plasmid vector to enhance cloning-mediated addition of restriction sites to a DNA fragment,”Biotechniques(1997) 23(5):814-816.
Coffin, J.M., “Retroviridae and Their Replication,” Chapter 51 ofVirology,Fields et al., eds., Raven Press, New York (1990) 1437-1500.
Couch, R.B. et al., “Immunization with types 4 and 7 adenovirus by selective infection of the intestinal tract,”Am. Rev. Resp. Dis.(1963) 88:394-403.
Davis, R.L. and Han, K-A., “Neuroanatomy: Mushrooming mushroom bodies,”Curr. Biol.(1996) 6(2):146-148.
Dealy, C.N. et al., “Wnt-5aanWnt-7aare expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes,”Mech. Dev.(1993) 43:175-186.
DeRossi, D., et al., “The Third Helix of the Antennapedia Homeodomain Translocates through Biological Membranes,”J. Biol. Chem.(1994) 269(14):10444-10450.
Dickson, B.J., “Molecular Mechanisms of Axon Guidance,”Science(2002) 298:1959-1964 plus Erratum, 1 page.
Ebens, A. et al., “Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons,”Neuron(1996) 17:1157-1172.
Elliott, G. and O'Hare, P., “Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein,”Cell(1997) 88:223-233.
Fan, C-M. et al., “A role for WNT proteins in induction of dermomyotome,”Dev. Biol.(1997) 191:160-165.
Fechheimer, M. et al., “Transfection of mammalian cells with plasmid DNA by scrape loading and sonication loading,”Proc. Natl. Acad. Sci. USA(1987) 84(23):8463-8467.
Felgner, P.L. et al., “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure,”Proc. Natl. Acad. Sci. USA(1987) 84:7413-7417.
Finch, P.W. et al., “Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action,”Proc. Natl. Acad. Sci. USA(1997) 94:6770-6775.
Fitzgerald, M.J.T.,Neuroanatomy Basic and Clinical(1996) W.B. Sauders Company Ltd., London (Cover and Table of Contents).
Fraley, R.T. et al., “Entrapment of a bacterial plasmid in phospholipid vesicles: Potential for gene transfer,”Proc. Natl. Acad. Sci. USA(1979) 76(7):3348-3352.
Francis, P.H. et al., “ Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb,”Development(1994) 120:209-218.
Frazer, S.E., “Iontophoretic Dye Labeling of Embryonic Cells,”Methods in Cell Biology(1996) Academic Press, Inc. 147-160.
Gabizon, A. et al., “Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: Biodistribution and imaging studies,”Cancer Res.(1990) 50:6371-6378.
Gavin, B.J. et al., “Expression of multiple novelWnt-1/int-1-related genes during fetal and adult mouse development,”Genes Dev.(1990) 4:2319-2332.
Glorioso, J.C. et al., “HSV as a gene transfer vector for the nervous system,”Mol. Biotechnol.(1995) 4:87-99.
Gopal, T.V., “Gene transfer method for transient gene expression, stable transformation, and cotransformation of suspension cell cultures,”Mol. Cell Biol.(1985) 5(5):1188-1190.
Graham, F.L. and Van Der Eb, A.J., “A new technique for the assay of infectivity of human adenovirus 5 DNA,”Virology(1973) 52:456-467.
Grunhaus, A. et al., “Association of vaccinia virus-expressed adenovirus E3-19K glycoprotein with class I MHC and its effects on virulence in a murine pneumonia model,”Virology(1994) 200(2):535-546.
Halford, M.M. et al., “Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk,”Nat. Genet.(2000) 25:414-418.
Hall, A.C. et al., “Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling,”Cell(2000) 100:525-535.
Harland, R. and Weintraub, H., “Translation of mRNA injected intoXenopusOocytes is specifically inhibited by antisenses RNA,”J. Cell Biol.(1985) 101:1094-1099.
Hofmann, C. et al., “Analysis of limb patterning in BMP-7-Deficient mice,”Dev. Genet.(1996) 19:43-50.
Joosten, E.A.J. et al., “Embryonic form of N-CAM and development of the rat corticospinal tract; immuno-electron microscopical localization during spinal white matter ingrowth,”Dev. Brain Res.(1996) 94:99-105.
Kamitori, K. et al., “Cell-type-specific expression of protein tyrosine kinase-related receptor RYK in the central nervous sytem of the rat,”Mol. Brain Res.(2002) 104:255-266.
Keino-Masu, K. et al., “Deleted in Colorectal Cancer(DCC) encodes a netrin receptor,”Cell(1996
Gamett Daniel C
Michael & Best & Friedrich LLP
Romeo David
The University of Chicago
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