Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2002-09-27
2009-06-09
Canella, Karen A (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S001100
Reexamination Certificate
active
07544465
ABSTRACT:
A three-dimensional reconstruct model containing solid layers of collagen and fibroblasts closely mimic the condition of patients in vivo, preserving in vivo phenotypic and functional characteristics of the cells. Reconstructs can be used to detect cellular migration, including active migration of cytotoxic T lymphocytes towards tumor cells, which can be measured by detecting tumor cell lysis. Reconstructs also can be used to identify factors that influence migration of cells, including chemokines that influence migration of cytotoxic T lymphocytes, as well as to identify tumor antigens.
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Herlyn Dorothee
Herlyn Meenhard
Somasundaram Rajasckharan
Banner & Witcoff , Ltd.
Canella Karen A
The Wistar Institute
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