Drug – bio-affecting and body treating compositions – Lymphokine
Reexamination Certificate
2011-05-10
2011-05-10
Bunner, Bridget E (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
C424S198100, C514S007600, C514S007900, C514S013500, C514S04400A, C530S350000, C530S351000, C530S399000
Reexamination Certificate
active
07939057
ABSTRACT:
Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use of adrenergic agonists that act in concert with a mobilization compound or agent. The mobilization agent(s) may act to decrease the expression or function of the chemokine, CXCL12, or may act to block or antagonize CXCR4. The invention also relates to methods of using these compounds or agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells is necessary for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating the symptoms associated with such diseases, disabilities or conditions. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.
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Battista Michela
Frenette Paul S.
Kao Wei-Ming
Bunner Bridget E
Klauber & Jackson LLC
Mount Sinai School of Medicine
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