Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2007-10-09
2007-10-09
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S006120
Reexamination Certificate
active
10826466
ABSTRACT:
Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the GC-Box 5 repressor site with a repressor protein (or protein complex including the same) is modulated to achieve the desired change in TERT expression. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like.
REFERENCES:
patent: WO 02/16657 (2002-02-01), None
patent: WO 02/16658 (2002-02-01), None
Nozawa, K. et al. J Biol Chem 276(25):22016-22023, 2001.
Horikawa, I. et al. PNAS 102(51):18437-18442, 2005.
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Oh, S. et al. Oncogene 19:1485-1490, 2000.
Andrews William H.
Briggs Laura
Foster Christopher A.
Fraser Stephanie
Mohammadpour Hamid
Bozicevic Field & Francis LLP
Falk Anne-Marie
Field Bret E.
Noble Marcia S.
Scherer David C.
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