Methods and compositions for modulating prostasin

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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07622265

ABSTRACT:
The invention provides methods and compositions related to modulating prostasin.

REFERENCES:
Adachi et al., “Activation of Epithelial Sodium Channels by Prostasin in Xenopus Oocytes”J Am Soc Nephrol12(6):1114-1121 (2001).
Benaud et al., “Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor”Eur J Biochem268(5) :1439-1447 (2001).
Bouton et al., “The Serpin Protease-Nexin 1 is Present in Rat Aortic Smooth Muscle Cells and is Upregulated in L-NAME Hypertensive Rats”Arterioscler Thromb Vasc Biol23(1):142-147 (Jan. 2003).
Chen et al., “Down-Regulation of Prostasin Serine Protease: A Potential Invasion Suppressor in Prostate Cancer”Prostate48 (2) :93-103 (Jun. 15, 2001).
Chen et al., “Prostasin is a Glycosylphosphatidylinositol-anchored Active Serine Protease”J Biol Chem276(24):21434-21442 (2001).
Chen et al., “Prostasin Serine Inhibits Breast Cancer Invasiveness and is Transcriptionally Regulated by Promoter DNA Methylation”Int. J Cancer97(3):323-329 (2002).
Chen et al., “Regulation of Prostasin Expression and Function in the Prostate”Prostate59(1):1-12 (2004).
Denda et al., “Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1”J Biol Chem.277(16):14053-14059 (Apr. 19, 2002).
Dennis et al., “Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display”J Biol Chem.270(43):25411-25417 (Oct. 27, 1995).
Donaldson et al., “Regulation of the Epithelial Sodium Channel by Serine Proteases in Human Airways”J Biol Chem277(10):8338-8345 (2002).
Fan et al., “Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin”J Biol Chem.280(41):34513-34520 (Oct. 14, 2005).
Graeber and Eisenberg, “Bioinformatic Identification of Potential Autocrine Signaling Loops in Cancers from Gene Expression Profiles”Nat. Genet.29(3):295-300 (Nov. 2001).
Itoh et al., “Genomic Structure and Chromosomal Localization of the Human Hepatocyte Growth Factor Activator Inhibitor Type 1 and 2 Genes”Eur J Biochem267(11):3351-3359 (2000).
Itoh.et al., “Upregulation of HGF Activator Inhibitor Type 1 but not Type 2 along with Regeneration of Intestinal Mucosa”Am J Physiol Gastrointest Liver Physiol.278(4):G635-G643 (2000).
Kataoka et al., “Activation of Hepatocyte Growth Factor/Scatter Factor in Colorectal Carcinoma”Cancer Research60:6148-6159 (Nov. 1, 2000).
Kataoka et al., “Distribution of hepatocyte growth factor activator inhibitor type.1 (HAI-1) in human tissues: Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues”J Histochem Cytochem.47(5):673-682 (May 1999).
Kataoka et al., “Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa”Cancer Lett.128(2):219-227 (Jun. 19, 1998).
Kataoka et al., “Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment”J Biol Chem275 (51) :40453-40462 (2000).
Kataoka et al., “Roles of Hepatocyte Growth Factor (HGF) Activator and HGF Activator Inhibitor in the Pericellular Activation of HGF/Scatter Factor”Cancer Metastasis Rev22(2) :223-236 (2003).
Kawaguchi et al., “Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor”J Biol Chem.272(44):27558-27564 (Oct. 31, 1997).
Kirchhofer et al., “Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1”J Biol Chem.278(38):36341-36349 (Sep. 19, 2003).
Kohler et al., “Continuous cultures of fused cells secreting antibody of predefined specificity”Nature256:495 (Aug. 7, 1975).
Lee et al., “Activation of Hepatocyte Growth Factor and Urokinase/Plasmingoen Activator by Matriptase, an Epithelial Membrane Serine Protease”Journal of Biological Chemistry275:36720-36725 (2000).
Lin et al., “Characterization of a Novel, Membrane-Bound, 80-kDa Matrix-Degrading Protease from Human Breast Cancer Cells. Monoclonal Antibody Production, Isolation, and Localization”J Biol Chem272(14):9147-9152 (Apr. 4, 1997).
Lin et al., “Purification and characterization of a complex containing matriptase and a kunitz-type serine protease inhibitor from human milk”J Biol Chem274(26):18237-18242 (Jun. 25, 1999).
Liu et al., “NetAffx: Affymetrix Probesets and Annotations”Nucleic Acids Res31(1):82-86 (2003).
Marlor et al., “Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains”J Biol Chem.272(18):12202-12208 (May 2, 1997).
Mok et al., “Prostasin, a Potential Serum Marker for Ovarian Cancer: Identification Through Microarray Technology”J Natl Cancer Inst.93(19):1458-1464 (Oct. 31, 2001).
Muthukumar et al., “Serine Proteinase Inhibitor-9, an Endogenous Blocker of Granzyme B/Perforin Lytic Pathway, is Hyperexpressed during Acute Rejection of Renal Allografts”Transplantation75(9):1565-1570 (2003).
Oberst et al., “Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters”Clin Cancer Res.8(4):1101-1107 (Apr. 2002).
Parr et al., “Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells”Int J Oncol.19(4):857-863 (Oct. 2001).
Phillips et al., “A role for the Granzyme B Inhibitor Serine Protease Inhibitor 6 in CD8+ Memory Cell Homeostasis”J Immunol.173(6):3801-3809 (2004).
Richard et al., “Protease Nexin-1: A Cellular Serpin Down-Regulated by Thrombin in Rat Aortic Smooth Muscle Cells”J Cell Physiol.201(1):138-145 (2004).
Shimomura et al., “Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor”Journal of Biological Chemistry272(10):6370-6376 (Mar. 7, 1997).
Shimomura, T. et al., “Multiple Sites of Proteolytic Cleavage to Release Soluble Forms of Hepatocyte Growth Factor Activator Inhibitor Type 1 from a Transmembrane Form”J Biochem(Tokyo) 126(5):821-828 (1999).
Shipway, A. et al., “Biochemical Characterization of Prostasin, a Channel Activating Protease”Biochem Biophys Res Commun.324(2):953-963 (2004).
Takahashi, S. et al., “Down-Regulated Expression of Prostasin in High-Grade or Hormone-Refractory Human Prostate Cancers”Prostate54(3):187-193 (2003).
Tong, Z. et al., “Prostasin, a Membrane-Anchored Serine Peptidase, Regulates Sodium Currents in JME/CF15 Cells, a Cystic Fibrosis Airway Epithelial Cell Line”Am J Physiol Lung Cell Mol Physiol.287:L928-L935 (Nov. 2004).
Tyagi et al., “Co-Expression of Tissue Inhibitor and Matrix Metalloproteinase in Myocardium”J Mol Cell Cardiol.27(10):2177-2189 (1995).
Yu et al., “Molecular Cloning, Tissue-specific Expression, and Cellular Localization of Human Prostasin mRNA”J Biol Chem.270(22):13483-13489 (Jun. 2, 1995).
Yu et al., “Prostasin is a Novel Human Serine Protenaise from Seminal Fluid Purification, Tissue Distribution, and Localization in Prostate Gland”J Biol Chem.269(29):18843-18848 (Jul. 22, 1994).

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