Methods and compositions for modulating Necdin function

Details Methods and compositions for modulating Necdin function Methods and compositions for modulating Necdin function

2006-04-04

2010-11-02

McGarry, Sean (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S091100, C435S325000, C435S375000

Reexamination Certificate

active

07825098

ABSTRACT:
Described herein are methods for identifying and using inhibitors of Necdin function to promote brown adipose tissue (BAT) differentiation, thereby treating obesity.

REFERENCES:
patent: WO 03/026576 (2003-04-01), None
Lu et al. (2005) “Delivering siRNA in vivo for functional genomics and novel therapies” in RNA Interference Technology, Appasaini, ed. (Cambridge University Press: Cambridge, UK) p. 303-307.
Samarsky et al. (2005) “RNAi in drug development: Practical considerations” in RNA Interference Technology Appasaini, ed. (Cambridge University Press: Cambridge, UK) p. 384-395.
Teng et al. (Nature Cell Biology, 2005 vol. 7:601-611).
Boeuf et al., “Differential gene expression in white and brown preadipocytes,” Physiol. Genomics 7:15-26 (2001).

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