Methods and compositions for modulating gamete adhesion

Details Methods and compositions for modulating gamete adhesion Methods and compositions for modulating gamete adhesion

2004-10-18

2008-10-21

Carlson, Karen Cochrane (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07439221

ABSTRACT:
Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one discoidin/C domain, and optionally at least one EGF domain. A representative polypeptide includes, but is not limited to SED1 polypeptides (SEQ ID NOs. 2-7), prodrugs, fragments, or derivatives thereof. Methods for identifying modulators of SED1-mediated gamete adhesion are also provided.

REFERENCES:
patent: 5972337 (1999-10-01), Ceriani et al.
patent: 1 004 644 (2000-02-01), None
patent: WO 03/016522 (2003-02-01), None
Kanai et al. 2000; Identification of a stromal cell type characterized by the secretion of a soluble integrin-binding protein, MFG-E8, in mouse early gonadogenesis. Mechanisms of Development 96: 223-227.
Stubbs et al. (1990; cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-lie sequences. PNAS 87:8417-8421.
Ogura et al. 1996; Cloning and expression of cDNA for O-acetylation of GD3 ganglioside. Biochem. Biophys Res. Commun. 225: 932-938.
Oshima et al. Feb. 2002; Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles: a possible role in membrane secretion. Eur. J. Biochem. 269: 1209-1218.

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