Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1994-04-22
1996-12-31
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530327, A61K 3702, C07K 1400, C07K 708
Patent
active
055895689
ABSTRACT:
The present disclosure relates to methods and compositions for modulating the action of G proteins. G proteins are important to cellular regulation in all human cells and their function is involved in a wide variety of human disease processes. In particular aspects, the present disclosure concerns the development of mastoparan analogs as well as other amphipathic and cationic peptides, termed receptor-based analogues, that can promote activation of one or more G proteins, and are therefore proposed to be useful in the treatment of a variety of disorders including asthma, ulcers, cardiovascular diseases and even Parkinson's disease.
REFERENCES:
Nishimoto et al., J. Biol. Chem., 266(19):12747-12751, 1991.
Dalman et al., J. Biol. Chem., 266(17):11025-11029, 1991.
Regoli & Nantel, Trends Pharmacol. Sci., 11:400-401, 1990.
Argiolas and Pisano, "Facilitation of Phospholipase A.sub.2 Activity by Mastoparans, a New Class of Mast Cell Degranulating Peptides form Wasp Venom," J. Biolog. Chem., 258(22):13697-13702, 1983.
Higashijima et al., "Mechanism of Histamine-Release by Mastoparan," Peptide Chemistry 1986, T. Miyazawa (Ed.), pp. 75-78, 1986.
Yajima et al., "Studies on Peptides. LXXXVI. Application of the Trifluoroacetic Acid-Thioanisole Deprotecting Procedures for the Synthesis of a Wasp Venom, Mastoparan," Chem. Pharm. Bull., 28(4):1214-1218, 1980.
International Search Report, mailed Nov. 18, 1992.
Tomita, U. et al., "Direct Interactions of Mastoparan and Compound 48/80 with GTP-Binding Proteins," J. Biochem., 109:184-189, 1991.
Tomita, U. et al., "Direct Activation of GTP-Binding Proteins by Venom Peptides that Contain Cationic Clusters Within Their Alpha-Helical Structures," Biochem. and Biophys. Res. Com., 178(1):400-406, 1991.
M unch, G. et al., "Multisite contacts involved in coupling of the .beta.-adrenergic receptor with the stimulatory guanine-nucleotide-binding regulatory protein," Eur. J. Biochem., 198:357-364, 1991.
Rubinfeld, B. et al., "A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21.sup.ras stimulation and promotes guanine nucleotide exchange," Int. J. Peptide Protein Res., 38:47-53, 1991.
Cheung, A. et al., "Specific activation of G.sub.s by synthetic peptides corresponding to an intracellular loop of the .beta.-adrenergic receptor," FEBS, 279(2):277-280, 1991.
Higashijima, T. et al., "Regulation of G.sub.i and G.sub.o by Mastoparan, Related Amphiphilic Peptides, and Hydrophobic Amines," J. Biol. Chem., 265(24):14176-14186, 1990.
Huang, R. et al., "Identification of Allosteric Antagonists of Receptor-Guanine Nucleotide-Binding Protein Interactions," Mol. Pharmaco., 37:304-310, 1990.
Okamoto, T. et al., "A Simple Structure Encodes G Protein-Activating Function of the IGF-II/Mannose 6-Phosphate Receptor," Cell, 62:709-717, 1990.
Mousli, M. et al., "Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 84/80," FEBS, 259(2):260-262, 1990.
K onig, B. et al., "Three cytoplasmic loops of rhodospin interact with transducin," Proc. Natl. Acad. Sci. USA, 86:6878-6882, 1989.
Higashijima, T. et al., "Mastoparan, a Peptide Toxin form WASP Venom, Mimics Receptors by Activating GTP-binding Regulatory Proteins (G Proteins)," J. Biol. Chem., 263(14):6491-6494, 1988.
Alberts, B. et al., Molecular Biology of the Cell, Second Edition, Garland Publishing, Inc., New York & London, 1989, pp. 694-699; 705-708.
Darnel, J. et al., Molecular Cell Biology, Scientific American Books, Inc., New York, 1986, pp. 679-697.
Wakamatsu, K. et al., "Action Mechanisms of Mastoparan, A Wasp Venom Peptide," Peptide Chemistry 1984, Ed. N. Izumiya, Protein Research Foundation, Osaka, Japan, 1985, pp. 183-186.
Higashijima, et al, J. Biol Chem., 265(24): 14176-14186, 1990.
Okamoto, et al, Cell, 62:709-717, 1990.
Higashijima Tsutomu
Ross Elliott M.
Board of Regents The University of Texas
Chan Christina Y.
Marshall S. G.
LandOfFree
Methods and compositions for modulating G protein action does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for modulating G protein action, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for modulating G protein action will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1142868