Methods and compositions for modulating drug activity...

Details Methods and compositions for modulating drug activity... Methods and compositions for modulating drug activity...

2006-02-02

2010-02-16

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S009200, C514S042000, C514S043000, C514S045000, C514S046000, C514S047000, C514S048000, C514S049000, C514S050000, C514S051000, C514S052000

Reexamination Certificate

active

07662361

ABSTRACT:
The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in combination) induces telomere damage and inhibits telomerase activity in the cancer cell. The method initially uses, e.g., a telomere damage-inducing agent such as paclitaxel, and a telomerase inhibitory agent such as AZT. The invention also provides methods for identifying other agents with telomere damage-inducing activity and/or telomerase inhibitory activity (as well as and compositions having such activity), for use in the treatment of cancer.

REFERENCES:
Henderson et al. The Journal of Cell Biology (1996), vol. 134, pp. 1-12.

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