Methods and compositions for modulating autoimmunity

Details Methods and compositions for modulating autoimmunity Methods and compositions for modulating autoimmunity

2006-01-10

2006-01-10

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S885000, C514S903000, C424S134100, C424S184100, C424S192100, C530S350000, C530S387300, C530S388220, C530S388700, C530S388730, C530S388750

Reexamination Certificate

active

06984625

ABSTRACT:
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits OX-2.

REFERENCES:
patent: 5434131 (1995-07-01), Linsley et al.
patent: 5916560 (1999-06-01), Larsen et al.
patent: 2002/0192215 (2002-12-01), Hoek et al.
patent: WO 97/21450 (1997-06-01), None
patent: WO 99/24565 (1999-05-01), None
P.L. Cohen “Systemic Autoimmunity” In Fundamental Immunology, Fourth edition, W.E. Paul, Editor, Lippincott-Raven Publishers, Philadelphia, 1999, Chapter 33, pp. 1067-1088.
Romagnani, Clin. Immunol. Immunopath. 1996; 80(3):225-235.
Steinman, Neuron 1999; 24:511-514.
Stuart et al. Lab. Invest. 1986; 54(1):1-3.
Bach in Immunol. Today 1993; 14(6):322-326.
Dick et al. J. Leukol. Biol. 74:161-166 (2003).
Hoek et al. Science 290: 1768-1771 (2000).
Broderick et al. Am J. Pathol. 161:1669-1677 (2002).
Expert Opin. Ther. Patents, 2003, 13: 711-715.
Nathan et al., Nature Immunology, 2001, 2 : 17-19.
Auchincloss, H., Jr. 1995 Transplantation Immunology, 211-218.
Barclay, 1981, Immunology, 44, pp. 727-736.
Barclay and Ward, 1982, European Journal Biochem, 129, pp. 447-452.
Borriello, F. et al., 1998, Mammalian Genome, Feb., 9(2), pp. 114-118.
Borriello, F. et al., 1997, J. Immunol, 158, pp. 4549-4554.
Chen, Z et al., Database Medline, 1997, Biochimica et Biophysica Acta, Nov. 28, 1362(1), pp. 6-10.
Gorczynski, R.M. et al., 1998, Transplantation, Apr. 27, 65(8), pp. 1106-1114.
Gorczynski, R.M. et al., 1999, J. Immunol. 163:1654-1660.
Preston, S. et al., 1997, European Journal of Immunology, vol. 27, No. 8, pp. 1911-1918.
Tang, et al., Pathogenesis of collagen-induced arthritis: modulation of disease by arthritogenic T-Cell epitope location, Journal of Immunology, vol. 113, pp. 384-391.
Myers et al., Characterization of a Peptide Analog of a Determinant of Type II Collagen That Suppresses Collagen-Induced Arthritis, Journal of Immunology, 1998, pp. 3589-3595.
Gorczynski, et al., Anti-CD200R Ameliorates Collagen-Induced Arthritis in Mice, Journal of Immunology, vol. 104, No. 3, Sep., 2002, pp. 256-264.
Chitnis et. al., The Role of CD200 in Immune-Modulation and Neural Protection in EAE, Abstract, 12thInternational Congress of Immunology and 4thAnnual Conference of FOCIS, Montreal, Jul., 21, 2004.
Hoek et al., Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200), Science, vol. 290, Dec. 1, 2000, pp. 1768-1771.
Broderick et. al. Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis, American Journal of Pathology, vol. 161, No. 5, Nov., 2002, pp. 1669-1677.
Dick et al., Control of Myeloid Activity During Retinal Inflammation, Journal of Leukocyte Biology, vol. 74, Aug., 2003, pp. 161-166.
Barclay et al., CD200 and membrane protein interactions in the control of myeloid cells, Trends in Immunology, vol. 23, No. 6, Jun. 2002.

Affiliated with

Also associated with

Rating

Methods and compositions for modulating autoimmunity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for modulating autoimmunity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for modulating autoimmunity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3560881