Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2008-10-20
2010-06-08
Romeo, David S (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C514S012200, C424S198100
Reexamination Certificate
active
07732567
ABSTRACT:
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
REFERENCES:
patent: 7455834 (2006-06-01), Desnoyers et al.
patent: 7456262 (2006-06-01), Desnoyers et al.
patent: WO 99/21998 (1999-05-01), None
patent: WO 01/53486 (2001-07-01), None
patent: WO 2004/003158 (2004-01-01), None
patent: WO 2005/025603 (2005-03-01), None
Hashimoto et al., (J Exp Med. Feb. 2, 1998;187(3):289-296).
Xu et al., Genes Dev. Mar. 1, 2000;14(5):585-595.
Soon et al., (J. Biol. Chem., vol. 278, Issue 13, 11465-11470, Mar. 28, 2003).
Desnoyers et al., “WISP-1 Binds (2001) to Decorin and Biglycan”Journal of Biological Chemistry276:47599-47607.
International Search Report for PCT/US2006/014008(Aug 24, 2006).
Pennica et al., “WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors”Proc. Natl. Acad. Sci. 95:14717-14722 (Dec. 1998).
Saxena , N. et al., “Differential expression of WSIP-1 and WISP-2 genes in normal and transformed human breast cell lines”Mol. Cell. Biochem. 228:99-104 (2001).
Soon et al., “Overexpression inhibition of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation”J. Biol. Chemistry278(13):11465-11470 (2003).
Xie, D. et al., “Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features”Cancer Research61:8917-8923 (2001).
Xu et al., “WISP-1 is a Wnt-1- and β-catenin-responsive oncogene”Gene&Develop. 14:585-595 (2000).
Desnoyers et al., “WISP-1 Binds to Decorin and Biglycan”Journal of Biological Chemistry276:47599-47607 (2001).
Soon et al., “Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation”J. Biol. Chemistry278 (13):11465-11470 (2003).
Desnoyers Luc
Filvaroff Ellen
Gamett Daniel C
Genentech Inc.
Romeo David S
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