Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2005-04-14
2008-11-25
Romeo, David (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C424S133100, C424S138100, C424S141100, C424S152100, C424S158100, C530S388100, C530S387900, C530S388240, C530S387700, C530S388800
Reexamination Certificate
active
07455834
ABSTRACT:
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
REFERENCES:
patent: WO 99/21998 (1999-05-01), None
patent: WO 01/53486 (2001-07-01), None
patent: WO 2004/003158 (2004-01-01), None
patent: WO 2005/025603 (2005-03-01), None
Desnoyers et al., “WISP-1 Binds to Decorin and Biglycan”Journal of Biological Chemistry276:47599-47607 (2001).
Soon et al., “Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation”J. Biol. Chemistry278(13):11465-11470 (2003).
Pennica D, et al., “WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors”Proc. Natl. Acad. Sci. USA95(25) :14717-14722 (Dec. 8, 1998).
Saxena , N. et al., “Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines”Mol. Cell. Biochem.228:99-104 (2001).
Xie, D. et al., “Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features”Cancer Research61:8917-8923 (2001).
Xu et al., “WISP-1 is a Wnt-1- and β-catenin-responsive oncogene”Gene&Develop.14 :585-595 (2000).
Desnoyer Luc
Filvaroff Ellen
Gamett Daniel C
Genentech Inc.
Romeo David
Ropp Traci H.
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