Methods and compositions for modulating activator protein 1

Details Methods and compositions for modulating activator protein 1 Methods and compositions for modulating activator protein 1

2003-11-05

2008-03-18

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100

Reexamination Certificate

active

07344833

ABSTRACT:
This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.

REFERENCES:
patent: 5989908 (1999-11-01), Scanlon
patent: 6312900 (2001-11-01), Dean et al.
patent: 2003/0148954 (2003-08-01), Bresnick et al.
patent: WO2004/043370 (2004-05-01), None
PCT International Search Report mailed Jun. 16, 2004 for International Application No. PCT/US03/35367.
Malek SN, Dordai Di, Reim J, Dintzis H, Desiderio S. Related Articles, Links Malignant transformation of early lymphoid progenitors in mice expressing an activated Bik tyrosine kinase. Proc Natl Acad Sci U S A. Jun. 23, 1998;95(13):7351-6.
Kyriakis J. Activation of the AP-1 Transcription Factor by Inflamatory Cytokines of the TNF Family. Gene Expression. 1999, vol. 7, pp. 217-213.
Pyrzynska B. et al. Changes of the Trans Activating Potential of AP-1 Transcription Factor During Cyctosporin A Induced Apoptosis of Clioma Cells Are Mediated by Phosphorylation and Alterations of AP-1 Composition. Journal of Neurochemistry. 2000, vol. 74, pp. 42-51.
Ozolins et al. Post-Translational Regulation of AP-1 Transcription Factor DNA Binding Activity in the Rat Conceptus. Molecular Pharmacology. 1999, vol. 56, No. 3, pp. 537-544.
BD Biosciences Clontech—Technical Info: pAP1 (PMA)- TA-Luc Vector. www.clonetech.com/techinfo/vectors/vectorsA-B/pAP1(PMA)- TA-Luc.shtml. 1 page, Accessed Jul. 25, 2001.
Acive Motif: TransAM AP-1. www.activemotif.com/products/cell/transam/ap1.html. 2 pages, Accessed Oct. 17, 2002.
Wisdom, Ron. AP-1: One Switch for Many Signals. Experimental Cell Research. 1999. vol. 253, pp. 80-185.

Affiliated with

Also associated with

Rating

Methods and compositions for modulating activator protein 1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for modulating activator protein 1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for modulating activator protein 1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3965253