Methods and compositions for modifying the surface of a...

Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus

Reexamination Certificate

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C204S616000, C204S454000

Reexamination Certificate

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10386581

ABSTRACT:
Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a biofouling resistant surfactant composition. At least a portion of the surfactant molecules of the composition are end modified with a non-reactive, charged end group that is charge stable over a pH range of about 2 to 12. The subject methods and compositions find particular use with electrophoretic devices, such as capillary electrophoretic devices.

REFERENCES:
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“Micro- and Nano-Scale Diagnostic techniques,” Ed. K.S. Bruer, Springer Verlag, New York, in press (2003)—3. Electrokinetic Flow Diagnostics, Devasenthipathy & Santiago, p. 124, Figure 3.2.
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Holmberg et al. (“Poly(ethylene glycol) grafting as a way to prevent protein adsorption and bacterial adherence,” Mittal Festschrift, 1998, pp. 443-460) (note that although published in 1998 (month unknown) the paper was presented at a Congress in Amsterdam held Oct. 16-20, 1995).
Ng et al. (′Prevention of protein adsorption on surfaces by polyethylene oxide-polypropylene oxide—polyethylene oxide triblock copolymers in capillary electrophoresis, Journal of Chromatography (1994), 659 (2), 427-34).
Entry for “polyacrylamide” in Hawley's Condensed Chemical Dictionary, 14th Edition, 2002.
Pratap Bahadur (′Block copolymers—their microdomain formation (in solid state) and surfactant behavior (in solution), Current Science, vol. 80, No. 8, Apr. 25, 2001).
Ren et al. (“Hydrophilic Polymer-Modified Polypropylene Hollow Fibers with Controllable Electroosmotic Flow for Capillary Electrophoresis,” J. Micro Sep. 8:535-540, 1996).
Ng et al. (′Prevention of protein adsorption on surfaces by polyethylene oxide-polypropylene oxide—polyethylene oxide triblock copolymers in capillary electrophoresis, Journal of Chromatography (1994), 659(2), 427-34).

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