Methods and compositions for mitigating pain

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07115661

ABSTRACT:
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceutical compositions are also described.

REFERENCES:
patent: 3869451 (1975-03-01), Phillipps et al.
patent: 4780560 (1988-10-01), Kumonaka et al.
patent: 4801596 (1989-01-01), Simon et al.
patent: 5049694 (1991-09-01), Bron et al.
patent: 5284872 (1994-02-01), Sandrock et al.
patent: 5428061 (1995-06-01), Sandrock et al.
patent: 5621000 (1997-04-01), Arena et al.
patent: 5661129 (1997-08-01), Feelisch et al.
patent: 5693676 (1997-12-01), Gorfine
patent: 5700947 (1997-12-01), Del Soldato
patent: 5780495 (1998-07-01), Del Soldato
patent: 5807847 (1998-09-01), Thatcher et al.
patent: 5861426 (1999-01-01), Del Soldato et al.
patent: 5883122 (1999-03-01), Thatcher et al.
patent: 5905086 (1999-05-01), Miura
patent: 6040341 (2000-03-01), Del Soldato et al.
patent: 6310052 (2001-10-01), Thatcher et al.
patent: 0664127 (1995-07-01), None
patent: WO 95/30641 (1995-11-01), None
patent: WO 97/46521 (1997-12-01), None
patent: WO 98/25918 (1998-06-01), None
patent: WO 98/42661 (1998-10-01), None
patent: WO 00/54756 (2000-09-01), None
Ferreira, S.H., et al., “Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin.”Euro. J. Pharmacol.217:207-209 (1992).
Lin, Q.,et al., “Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates.”J. Neurosci.17(9):3293-3302 (1997).
Mashimo, T., et al., “Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1on primary afferent nociceptors in humans.”J. Clin. Pharmacol.37:330-335 (1997).
Aley, K.O., G. McCarter, and J.D. Levin, “Nitric Oxide Signaling in Pain and Nociceptor Sensitization in the Rat.” J. Neurosci. 18 (1998) 7008-7014.
Artz, J.D. and G.R.J. Thatcher, “NO Release from NO Donors and Nitrovasodilators: Comparisons between Oxyhemoglobin and Potentiometric Assays.” Chem. Res. Toxicol. 11 (1998) 1393-1397.
Bak, A.W., W. McKnight, P. Li, P. Del Soldato, A. Calignano, G. Cirino and J.L. Wallace, “Cyclooxygenase-Independent Chemoprevention with an Aspirin Derivative in a Rat Model of Colonic Adenocarcinoma.” Life Sci. 62 (1998) 367-373.
Barger, S.W., R.R. Fiscus, P. Ruth, F. Hofmann, M.P. Mattson, “Role of Cyclic GMP in the Regulation of Neuronal Calcium and Survival By Secreted Forms of β-Amyloid Precursor.” J. Neurochem. 64 (1995) 2087-2096.
Bennett, B.M., B.J. McDonald, R. Nigam, P.G. Long, and W.C. Simon, “Inhibition of Nitrovasodilator- and Acetylcholine-Induced Relaxation and Cyclic GMP Accumulation by the Cytochrome P-450 Substrate, 7-Ethoxyresorufin.” Can. J. Physiol. Pharmacol. 70 (1992) 1297-1303.
Berge, S.M., L.D. Bighley, and D.C. Monkhouse, “Pharmaceutical Salts.” J. Pharm. Sci. 66 (1977) 1-19.
Bloeman, P.G.M., P.A.J. Henricks, L. van Bloois, M.C. van den Tweel, A.C. Bloem, F.P. Nijkamp, D.J.A. Crommelin, and G. Storm, “Adhesion Molecules: a New Target for Immunoliposome-Mediated Drug Delivery.” FEBS Lett. 357 (1995) 140-144.
Cunha, F.Q., M.M. Teixeira and S.H. Ferreira, “Pharmaceological Modulation of Secondary Mediator Systems-Cyclic AMP and Cyclic GMP—on Inflammatory Hyperalgesia.” Br. J. Pharmacol. 127 (1999) 671-678.
del Soldato, P.R. Sorrentino and A. Pinto, “NO-aspirins: a Class of New Anti-inflammatory and Antithrombotic Agents.” TiPS 20 (1999) 319-323.
Ferreira, S.H., “The Role of Interleukins and Nitric Oxide in the Mediation of Inflammatory Pain and its Control by Peripheral Analgesics.” Drugs 46 (1993) 1-9.
Ferreira, S.H., I.D.G. Duarte and B.B Lorenzetti, “Molecular Base of Acetylcholine and Morphine Analgesia.” AAS 32 (1991) 101-106.
Fidecka, S. and Lalewicz, “Studies on the Antinociceptive Effects of Sodium Nitroprusside and Molsidomine in Mice.” Polish J. Pharmacol. 49 (1997) 395-400.
Granados-Soto, V., M. de O. Rufino, L.D.G. Lopes, S.H. Ferreira, “Evidence for the Involvement of the Nitric Oxide-cGMP Pathway in the Antinociception of Morphine in the Formalin Test.” Euro. J. Pharmacol. 340 (1997) 177-180.
Inoue, T., M. Takashi, S. Shibuta, I. Yoshiya, “Intrathecal Administration of a New Nitric Oxide Donor, NOC-18, Produces Acute Thermal Hyperalgesia in the Rat.” J. Neurol. Sci. 153 (1997) 1-7.
Lauretti, G.R., I.C.P.R. Lima, M.P. Reis, W.A. Prado, N.L. Pereira, “Oral Ketamine and Transdermal Nitroglycerin as Analgesic Adjuvants to Oral Morphine Therapy for Cancer Pain Management.” Anesthesiology 90 (1999) 1528-1533.
Louw, R., H.P.W. Vermeeren, J.J.A. Van Asten, and W.J. Ultée, “Reaction of Sulphides with Acyl Nitrates; a Simple and Rapid Method for Preparing Sulphoxides.” J. C .S. Chem. Comm. (1976) 496-497.
Macdonald, R.L. and M. Stoodley, “Pathophysiology of Cerebral Ischemia.” Neurol. Med. Chir. (Tokyo) 38 (1998) 1-11.
Malmberg, A.B. and T.L. Yaksh, “Pharmacology of the Spinal Action of Ketorolac, Morphine, ST-91, U50488H, and L-PIA on the Formalin Test and an Isobolographic Analysis of the NSAID Interaction.” Anesthesiology 79 (1993) 270-281.
McDonald, B.J. and B.M. Bennett, “Cytochrome P-450 Mediated Biotransformation of Organic Nitrates.” Can. J. Physiol. Pharmacol. 68 (1990) 1552-1557.
McGuire J.J., D.J. Anderson and B.M. Bennett, “Inhibition of the Biotransformation and Pharmacological Actions of Glyceryl Trinitrate by the Flavoprotein Inhibitor, Diphenyleneiodonium Sulfate.” J. Pharmacol. Exp. Ther. 271 (1994) 708-714.
Ouellette, R.J., and R.J. Bertsch, “Formation of Nitrate Esters by the Oxidation of Alkenes and Cyclopropanes with Thallium (III) Nitrate in Pentane.” J. Org. Chem. 41 (1976) 2782-2783.
Owais, M., G.C. Varshney, A. Choudhury, S. Chandra, and C.M. Gupta, “Chloroquine Encapsulated in Malaria-Infected Erythrocyte-Specific Antibody-Bearing Liposomes Effectively Controls Chloroquine-ResistantPlasmodium bergheiInfections in Mice.” Antimicrob. Agents Chemother. 39 (1995) 180-184.
Ranade, V.V., “Drug Delivery Systems. 1. Site-Specific Drug Delivery Using Liposomes as Carriers.” J. Clin. Pharmacol. 29 (1989) 685-694.
Reynolds, J.N. and R. Maitra, “Propofol and Flurazepam Act Synergistically to Potentiate GABAAReceptor Activation in Human Recombinant Receptors.” Euro. J. Pharmacol. 314 (1996) 151-156.
Salter, M., P.J.L.M. Strijbos, S. Neale, C. Duffy, R.L. Follenfant and J. Garthwaites, “The Nitric Oxide-Cyclic GMP Pathway is Required for Nociceptive Signalling at Specific Loci within the Somatosensory Pathway.” Neuroscience 73 (1996) 649-655.
Shibuta, S., T. Mashimo, P. Zhang, A. Ohara, I. Yoshiya, “A New Nitric Oxide Donor, NOC-18, Exhibits a Nociceptive Effect in the Rat Formalin Model.” J. Neurol. Sci. 141 (1996) 1-5.
Stewart, D.H., L.D. Hayward, and B.M. Bennett, “Differential Biotransformation of the Enantiomers of Isoidide Dinitrate in Isolated Rat Aorta.” Can. J. Physiol. Pharmacol. 67 (1989) 1403-1408.
Stone, J.R. and M.A. Marletta, “Spectral and Kinetic Studies on the Activation of Soluble Guanylate Cyclase by Nitric Oxide.” Biochem: 35 (1996) 1093-1099.
Strejan, G.H., J.J. Gilbert, and J. St. Louis, “Suppression of Chronic-Relapsing Experimental Allergic Encephalomyelitis in Strain-13 Guinea Pigs by Administration of Liposome-Associated Myelin Basic Protein.” J. Neuroimmunol. 7 (1984) 27-41.
Sydserff, S.G., A.J. Cross, K.J. West, and A.R. Green, “The Effect of Chlormethiazole on Neuronal Damage in a Model of Transient Focal Ischaemia.” Br. J. Pharmacol. 114 (1995) 1631-1635.
Thatcher, Gregory R.J. and Hazel Weldon, “NO problem for nitroglycerin: organic nitra

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions for mitigating pain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for mitigating pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for mitigating pain will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3681767

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.