Methods and compositions for mineralizing calcified tissues

Drug – bio-affecting and body treating compositions – Dentifrices – Phosphate compound containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424602, A61K 716, A61K 3306

Patent

active

050376390

ABSTRACT:
This invention involves the use of amorphous calcium compounds such as: amorphous calcium phosphate (ACP), amorphous calcium phosphate fluoride (ACPF) and amorphous calcium carbonate phosphate (ACCP) for use in remineralizing teeth. These amorphous compounds or solutions which form the amorphous compounds, when applied either onto or into dental tissue prevent and/or repair dental weaknesses such as dental caries, exposed roots and dentin sensitivity. The compounds have the highest solubilities, fastest formation rates and fastest conversion rates (to apatite) among all the calcium phosphorate under physiological conditions. Moreover, in the presence to fluoride the amorphous compound convert rapidly to fluoride containing apatite.

REFERENCES:
patent: 1225362 (1917-05-01), Ruthrauff
patent: 2605229 (1952-07-01), Marcus
patent: 3679360 (1972-07-01), Rubin et al.
patent: 3913229 (1975-10-01), Driskell et al.
patent: 3943267 (1976-03-01), Randol
patent: 4048300 (1977-09-01), Tomlinson et al.
patent: 4080440 (1978-03-01), Diguilio et al.
patent: 4108980 (1978-08-01), Duff
patent: 4143128 (1979-03-01), Kim et al.
patent: 4144324 (1979-03-01), Crutchfield et al.
patent: 4327079 (1982-04-01), Aoki
patent: 4342741 (1982-08-01), Aoki
patent: 4348381 (1982-09-01), Gaffar et al.
patent: 4397837 (1983-08-01), Raaf et al.
patent: 4405600 (1983-09-01), Besic
patent: 4515770 (1985-05-01), Besic
patent: 4518430 (1985-05-01), Brown et al.
patent: 4556561 (1985-12-01), Brown et al.
patent: 4606912 (1986-08-01), Rudy et al.
patent: 4610873 (1986-09-01), Rudy et al.
patent: 4612053 (1986-09-01), Brown et al.
patent: 4634589 (1987-01-01), Scheller
patent: 4672032 (1987-06-01), Slavkin et al.
patent: 4710372 (1987-12-01), Scheller
patent: 4908211 (1990-03-01), Paz
patent: 4923683 (1990-05-01), Sakuma et al.
Tung et al., "Hydrolysis of Dicalcium Phosphate Dihydrate in the Presence or Absence of Calcium Fluoride" Basic Biol. Sciences; Dent, J. Res. 64(1):2-5, Jan., 1985.
Patel, P. R. et al., "Solubility of CaHPO.sub.4 .times.2H.sub.2 O in the Quaternary System Ca(OH).sub.2 -H.sub.3 PO.sub.4 -NaCl-H.sub.2 O at 25.degree. C." J. Res. Nat. Bur. Stand.
Brown, W. et al., "Crystallography of Tetracalcium Phosphate" J. Res. Nat. Bur. Stand. 69A 547-551 (1965).
Moreno, E. et al., "Stability of Dicalcium Phosphate Dihydrate in Aqueous Solutions and Solubility of Octocalcium Phosphate" Soil Science Society Proceedings, 1960.
McDowell et al., "Solubility of Ca.sub.5 (PO.sub.4).sub.3 .times.in the System Ca(OH).sub.2 -H.sub.3 PO.sub.4 -H.sub.2 O at 5, 15, 25 and 37.degree. C." J. Res. Nat. Bur. Stand. 81A 273-281 (1977).
Gregory, T. M. et al., "Solubility of B-Ca.sub.3 (PO.sub.4).sub.2 in the System Ca(OH).sub.2 -H.sub.3 PO.sub.4 -H.sub.2 O at 5, 15, 25 and 37.degree. C." J. Res. Nat. Bur. Stand. 78A 667-674 (1974).
Gregory, T. M. et al., "Solubility of CaHPO.sub.4 .times.2H.sub.2 O in the System Ca(OH).sub.2 -H.sub.3 PO.sub.4 -H.sub.2 O at 5, 15, 25, and 37.5.degree. C.," J. Res. Nat. Nat. Bur. Stand 74A 461-475 (1970).
Driskell et al., "Development of Ceramic and Ceramic Composite Devices for Maxillofacial Applications" J. Biomed. Mater. Res. Symposium; 345-361.
Levine, R. S. et al., "Remineralisation of Natural Carious Lesions of Enamel In Vitro" Brit. Dent. J., 1974; 137, 132 Dental Caries Dental Enamel: Hydroxyapatite: 132-134.
Zimmerman et al., "The Effect of Remineralization Fluids on Carious Lesions In Vitro" IADR Abstract No. 282 (1979).
Silverstone et al., "Progressions of Caries-Like Lesions In Vitro After Exposure to Synthetic Calcifying Fluids" IADR Abstract No. 283 (1979).
Wefel, J. S. et al., "Artificial Lesion Formation in TiF.sub.4 and APF Treated Enamel" IADR Abstract No. 284 (1979).
Crall, J. J. et al., "Artificial Lesion Formation and Progression after Two-Step Topical Fluorides" IADR Abstract No. 285 (1979).
Hiatt, W. H. et al., "Root Preparation I. Obturation of Dentinal Tubules in Treatment of Root Hypersensitivity" J. Peridontal: 373-380 (1972).
Gelhard, T. B. F. M., "Rehardening of Artificial Enamel Lesions in Vivo" Caries Res. 13:80-83 (1979).
Silverstone, "Remineralization Phenomena" Caries Res. 11 (Suppl. 1):59-84 (1977) Briner.
Briner, W. W., "Significance of Enamel Remineralization" 53 239-243 (1974).
NASA and Dentistry, "New Tooth Enamel from Brushite Crystals" (Oct., 1977).
Pickel, F. D., "The Effects of a Chewing Gum Containing Dicalcium Phosphate on Salivary Calcium and Phosphate" Ala. J. Med: 286-287 (1965).
Trautz, "Crystallographic Studies of Calcium Carbonate Phosphate" Annals of the N.Y. Acad. Sci. 35, Article 1: 145-160 (1960).
Blumenthal, N. C. et al., "Effect of Preparation Conditions on the Properties and Transformation of Amorphous Calcium Phosphate" Mat. Res. Bull. 7: 1181-1190 (1972).
Posner, A. S. et al., "Synthetic Amorphous Calcium Phosphate and its Relation to Bone Mineral Structure" Accts. of Chem. Res. 8 273-281 (1975).
Tung, M. S. et al., "An Intermediate State in Hydrolysis of Amorphous Calcium Phosphate" Calcif Tissue Int. 783-790 (1983).
LeGeros, R. Z., "Apatitic Calcium Phosphates: Possible Dental Restorative Materials" IADR Abstract No. 1482 J. Dent. Res. 61 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions for mineralizing calcified tissues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for mineralizing calcified tissues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for mineralizing calcified tissues will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1985796

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.