Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1993-08-09
1995-08-01
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 48, 424 49, 424 57, 424602, 106 35, 4331991, 433215, 4332221, 4332281, A61K 716, A61K 718, A61K 912
Patent
active
054378575
ABSTRACT:
This invention involves the use of amorphous calcium compounds such as: amorphous calcium phosphate (ACP), amorphous calcium phosphate fluoride (ACPF) and amorphous calcium carbonate phosphate (ACCP) for use in remineralizing teeth. These amorphous compounds or solutions which form the amorphous compounds, when applied either onto or into dental tissue prevent and/or repair dental weaknesses such as dental caries, exposed roots and dentin sensitivity. The compounds have the highest solubilities, fastest formation rates and fastest conversion rates (to apatite) among all the calcium phosphorate under physiological conditions. Moreover, in the presence to fluoride the amorphous compound convert rapidly to fluoride containing apatite.
REFERENCES:
patent: Re33161 (1990-02-01), Brown et al.
patent: Re33221 (1990-05-01), Brown et al.
patent: 1225362 (1917-05-01), Ruthrauff
patent: 2605229 (1952-07-01), Marcus
patent: 3679360 (1972-07-01), Rubin et al.
patent: 3913229 (1975-10-01), Driskell et al.
patent: 3943267 (1976-03-01), Randol
patent: 4048300 (1977-09-01), Tomlinson et al.
patent: 4080440 (1978-03-01), Diguilio et al.
patent: 4108980 (1978-08-01), Duff
patent: 4143128 (1979-03-01), Kim et al.
patent: 4144324 (1979-03-01), Crutchfield et al.
patent: 4177258 (1979-12-01), Gaffar et al.
patent: 4183915 (1980-01-01), Gaffar et al.
patent: 4283385 (1981-08-01), Dhabhar et al.
patent: 4327079 (1982-04-01), Aoki
patent: 4342741 (1982-08-01), Aoki
patent: 4397837 (1983-08-01), Raaf et al.
patent: 4405600 (1983-09-01), Besic
patent: 4434381 (1983-09-01), Gaffar et al.
patent: 4515770 (1985-05-01), Besic
patent: 4518430 (1985-05-01), Brown et al.
patent: 4532124 (1985-07-01), Pearce
patent: 4556561 (1985-12-01), Brown et al.
patent: 4606912 (1986-08-01), Rudy et al.
patent: 4610873 (1986-09-01), Rudy et al.
patent: 4612053 (1986-09-01), Brown et al.
patent: 4634589 (1987-01-01), Scheller
patent: 4672032 (1987-06-01), Slavkin et al.
patent: 4710372 (1987-12-01), Scheller
patent: 4714608 (1987-12-01), Rolla
patent: 4880610 (1989-11-01), Constantz
patent: 4908211 (1990-03-01), Paz
patent: 4923683 (1990-05-01), Sakuma et al.
patent: 5034059 (1991-07-01), Constantz
patent: 5037639 (1991-08-01), Tung
patent: 5047031 (1991-09-01), Constantz
patent: 5053212 (1991-10-01), Constantz et al.
patent: 5129905 (1992-07-01), Constantz
patent: 5145668 (1982-09-01), Chow et al.
patent: 5268167 (1993-12-01), Tung
Tung, et al. "Hydrolysis of Dicalcium Phosphate Dihydrate In The Presence Or Absence Of Calcium Fluoride" Basic Biol. Sciences; Dent, J. Res. 64(1): 2-5 Jan., 1985.
Patel, P. R., et al. "Solubiltiy of CaHPO.sub.4 .times.2H.sub.2 O In The Quaternary System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --NaCl-H.sub.2 O at 25.degree. C." J. Res. Nat. Bur. Stand.
Brown, W., et al. "Crystallography Of Tetracalcium Phosphate"]J. Res. Nat. Bur. Stand. 69A 547-551 (1965).
Moreno, E., et al. "Stability of Dicalcium Phosphate Dihydrate In Aqueous Solutions and Solubility Of Octocalcium Phosphate" Soil Science Society Proceedings, 1960.
McDowell, e tal. "Solubility of Ca.sub.5 (PO.sub.4).sub.3 x In The System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --H.sub.2 O at 5, 15, 25 and 37.degree. C." J. Res. Nat. Bur. Stand. 81A 273-281 (1977).
Gregory, T. M. et al. "Solubility of B-CA.sub.3 (PO.sub.4).sub.2 In The System Ca(OH).sub.2 -H.sub.3 PO.sub.4 -H.sub.2 O at 5, 15, 25 and 37.degree. C." J. Res. Nat. Bur. Stand. 78A 667-674 (1974).
Gregory, T. M., et al. "Solubility of CaHPO.sub.4 .times.2H.sub.2 O in the System Ca(OH).sub.2 -H.sub.3 PO.sub.4 --H.sub.2 O at 5, 15, 25, and 37.5.degree. C.". J. Res. Nat. Bur. Stand 74A 461-475 (1970).
Driskell, et al. "Development of Ceramic and Ceramic Composite Devices For Maxillofacial Applications" J. Biomed. Mater. Res. Symposium; 345-361.
Levine, R. S. et al. "REmineralisation Of Natural Carious Lesions Of Enamel In Vitro" Brit. dent. J., 1974; 137, 132 Dental Caries Dental Enamel: Hydroxyapatite: 132-134.
Zimmerman, et al. "The Effect Of Remineralization Fluids On Carious Lesions In Vitro" IADR Abstract No. 282 (1979).
Silverstone, et al. "Progressions Of Caries-like Lesions In Vitro After Exposure To Synthetic Calcifying Fluids" IADR Abstract No. 283 (1979).
Wefel, J. S., et al. "Artificial Lesion Formation In TiF.sub.4 and APF Treated Enamel" IADR Abstract No. 284 (1979).
Crall, J. J., et al. "Artificial Lesion Formation and Progression after Two-step Topical Fluorides" IADR Abstract No. 285 (1979).
Hiatt, W. H., et al. "Roof Preparation I. Obturation of Dentinal Tubules In Treatment Of Root Hypersensitivity": J. Peridonatal: 373-380 (1972).
Gelhard, T. B. F. M., "Rehardening Of Artificial Enamel Lesions In Vivo" Caries Res. 13: 80-83 (1979).
Silverstone, "Remineralization Phenomena" Caries Res. 11 (Suppl. 1): 59-84 (1977).
Briner, W. W., "Significance Of Enamel Remineralization" 53 239-243 (1974).
NASA And Dentistry, "New Tooth Enamel From Brushite Crystals" (Oct., 1977).
Pickel, F. D. "The Effects Of A Chewing Gum Containing Dicalcium Phosphate On Salivary Calcium And Phosphate" Ala. J. Med: 286-87 (1965).
Trautz, "Crystallographic Studies Of Calcium Carbonate Phosphate" Annals of the N.Y. Acad. Sci. 35, Article 1: 145.160 (1960).
Blumenthal, N. C. et al., "Effect Of Preparation Conditions On The Properties And Transformation Of Amorphous Calcium Phosphate" Mat. Res. Bull. 7: 1181-1190 (1972).
Posner, A. S. et al. "Synthetic Amorphous Calcium Phosphate And Its Relation To Bone Mineral Structure" Accts. Of Chem. Res. 8 273-281 (1975).
Tung, M. S., et al. "An Intermediate State In Hydrolysis Of Amorphous Calcium Phosphate" Calcif Tissue Int. 783-790 (1983).
LaGeros, R. Z., "Apatitic Calcium Phosphates: Possible Dental Restorative Materials" IADR Abstract No. 1482 J. Dent. Res. 61 (1982).
Tung, M. S., et al. "The Effects of Calcium Phosphate Solutions on Permeability of Dentin" J. Dent. Res., 65 Abstract No. 167 (1986).
Brown, et al., "Singular Points in the Chemistry of Teeth," IADR Abstract No. 120, J. Dent. Res. 54:74 (1975).
Guide To Dental Materials And Devices, 7 Ed. p. 49 (ADA 1974).
Ababa Takaaki, et al. "Small-Angle X-Ray Scattering Study On The Transformation Of Amorphous Calcium Phosphate To Crystalline Apatite," Chem. Abstracts, vol. 91 No. 13, Abstract No. 105934q (1979).
Ababa Takaaki, "X-Ray Diffraction Study On The Amorphous And Crystalline Components in Bone Mineral" Chem. Abstracts, vol. 91, No. 13, Abstract No. 1 (1979).
Termine, John D., et a. "Calcium Phosphate In Vitro" Chem. Abst. vol. 73 Abstract No. 126985a (1970).
Hong, Y. C., et al. (1989): "The Periapical Tissue Reactions To A Calcium Phosphate Cement In The Teeth Of Monkeys", J. Dent. Res. (submitted).
McDowell, et al., "Solubility Study Of Calcium Hydrogen Phosphate. Ion-Pair Formation," Inorg. Chem. 10:1638-1643 (1971).
Tung, et al. "Effects of Calcium Phosphate Solutions on Dentin Permeability" vol. 19 No. 8, J. of Endodontic (1983).
Brown, "Solubilities of Phosphates and Other Sparingly Soluble Compounds" from Griffith, et al., Environmental Phosphorous Handbook (John Wiley & Sons New York 1973).
DeRijk, et al. (1986) "Clinical Evaluation of an Hydroxyapatite Precipitate for the Treatment of Dentinal Hypersensitivity" Biomedical Engineering V. Recent Developments, Proc of 5th Southern Biomedical Engineering Conference, Subrate Saha, Ed., New York: Pergamon Press, pp. 336-339.
Lu, et al., (1988) "New Attachment Following the Use of Novel Calcium Phosphate System" J. Dent. Res. 67:352, Abst. No. 1913.
Schreiber, et al. (1988) "Remineralization of Root Caries Lesion by a Calcium Phosphate Slurry," J. Dent. Res. 67:Abst. No. 255.
Sugawara, et al. (1987) "A Calcium Phosphate Root Canal Sealer-Filler" J. Dent. Res. 66:296 Abst. No. 1516.
Sugawara et al. (1988) "Formation of Hydroxyapatite in Hydrogels from Tetracalcium Phosphate/Dicalcium Phosphate Mixtures," J. Dent. Res. (submitted).
Matsuya et al. "Effects of pH on the Reactions of Tetracalcium Phosphate and Dicalcium Phosphate" IADR Abstracts 1991.
Tamotsu et al. "Synthesis and Characteristics of Amorphous Calcium Carbonate in Ethanol" Chem. Sb. vol. 103, No.
American Dental Association - Health Foundation
Griffin Ronald W.
LandOfFree
Methods and compositions for mineralizing and fluoridating calci does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for mineralizing and fluoridating calci, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for mineralizing and fluoridating calci will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-732715