Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-01-11
1993-11-09
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 2, 424617, 436173, 436806, 1286534, 556 61, 536102, 536112, 536122, G01N 2408, C07F 1900, C07H 2300, A61K 3324
Patent
active
052600505
ABSTRACT:
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for nuclear magnetic resonance imaging. A polyatomic complex which includes intramolecular ferromagnetic coupling between metal atoms is associated with a polymer or microsphere carrier matrix which will bind to endothelial determinants. A solution containing this carrier complex is injected into a human (or other) body to be imaged. The carrier complex will preferentially extravasate at locations where the blood vessel walls have increased porosity or microvascular surface changes, and especially at tumor sites. Thus, the changes in relaxation time induced by the presence of the carrier complex will provide a high-gain marker for magnetic resonance imaging.
Multiple superparamagnetic polyatomic complexes are described, including novel complexes which include acetate and glycinate bridging ligands with a polyatomic metal-atom-complex core.
REFERENCES:
patent: 4423158 (1983-12-01), Porath
patent: 4452773 (1984-06-01), Molday
patent: 4474866 (1984-10-01), Ziolo
patent: 4647447 (1987-03-01), Gries et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4735210 (1988-04-01), Goldenberg
patent: 4735796 (1988-04-01), Gordon
patent: 4770183 (1988-09-01), Groman
patent: 4827945 (1989-05-01), Groman et al.
patent: 4832877 (1989-05-01), Bino
patent: 4849210 (1989-07-01), Widder
patent: 4951675 (1990-08-01), Groman et al.
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4965007 (1990-10-01), Yudelson
Bruner, Henri Chem. Abstracts 100:210,064h (1984).
Eremenko, Il. Chem. Abstracts 112:139311b (1990).
Komura, Y. Chem. Abstracts, 101:31379p (1984).
Lauffer et al., "Preparation and Water Relaxation Properties of Proteins Labeled with Paramagnetic Metal Chelates," Mag. Res. Imag. (1985) 3:11-16.
Bino et al. "[Cr.sub.4 S(O.sub.2 CCH.sub.3).sub.8 (H.sub.2 O).sub.4 ](BF.sub.4).sub.2 .multidot.H.sub.2 O: Ferromagnetically Coupled Cr.sub.4 S Cluster with Spin 6 Ground State", Science, (1988) 241:1479-81.
Gallo et al., Pharmaceutical Research, 5:300-304 (1988).
International Search Report for International Application No. PCT/US89/04295, Jan. 8, 1990.
Hollinden Gary E.
Hollrah Glennon H.
LandOfFree
Methods and compositions for magnetic resonance imaging comprisi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for magnetic resonance imaging comprisi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for magnetic resonance imaging comprisi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1141119