Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-04-03
1994-07-19
Dees, Jos',acu/e/ G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
514492, 436173, 436806, 556 49, 546 2, 1286534, G01N 3100, A61K 4900, C07F 1300
Patent
active
053307429
ABSTRACT:
Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a paramagnetic metal cluster. Magnetic resonance contrast media containing Z+[Mn.sub.12 X.sub.12 (OYR).sub.16 (L).sub.4 ], where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion are disclosed. Z may also be a paramagnetic counter ion, such as a high spin metal cluster. The paramagnetic cluster may optionally be complexed or conjugated to a carrier compound capable of altering the paramagnetic metal cluster's biodistribution, increasing its selectivity of tumor localization, and amplifying its proton relaxivity.
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John B. Vincent, et al., "Preparation of Physical Properties of Trinuclear Oxo-Centered Manganese Complexes of the General Formulation [Mn.sub.3 O(O.sub.2 CR).sub.6 L.sub.3 ].sup.0,+ (R=Me or Ph; L=a Neutral Donor Group) . . . " Journal of the American Chemical Society, vol. 19, pp. 5703-5711 (1987).
Peter D. W. Boyd, et al., "Potential Building Blocks for Molecular Ferromagnetics: Mn.sub.12 O.sub.12 (O.sub.2 CPh).sub.16 (H.sub.2 O).sub.4 ] with a S=14 Ground State", Journal of the American Chemical Society, vol. 110, pp. 8537-8539 (1988).
Abstract No. 795, 203rd Meeting of the American Chemical Society, San Francisco, Calif., Apr. 5-10, 1992.
Deutsch Edward A.
Moore Dennis A.
Dees Jos',acu/e/ G.
Mallinckrodt Medical Inc.
Nazario Porfirio
Stierwalt Brian K.
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