Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Lipid or oil
Reexamination Certificate
2006-05-30
2006-05-30
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Lipid or oil
C424S194100, C435S130000, C530S300000, C530S350000, C536S022100
Reexamination Certificate
active
07052704
ABSTRACT:
Fatty acid derivatives of sulfhydryl-containing compounds (for example, sulfhydryl-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in the cells and thus facilitates intracellular release of the intact compounds from the fatty acid moieties.
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Ekrami Hossein M.
Shen Wei-Chiang
Desai Anand U.
Sterne Kessler Goldstein & Fox PLLC
University of Southern California
Weber Jon
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