Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-06-06
1997-04-08
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514449, 514510, A61K 3578
Patent
active
056185383
ABSTRACT:
Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of drying plant matter to preserve their taxane content and facilitate their extraction is disclosed. In addition, methods of extracting and purifying taxol and other taxanes from ornamental cultivars using a series of organic and aqueous solvents and normal phase chromatography columns are also disclosed.
REFERENCES:
patent: 4206221 (1980-06-01), Miller et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 5019504 (1991-05-01), Christen et al.
Vidensek, N., et al., Taxol Content in Bark, Wood, Root, Leaf, Twig, and Seedling From Several Taxus Species, Journal of Natural Products (1990) 53(6): 1609-1610.
National Products Branch, National Cancer Institute, description of taxol dated Jul. 15, 1983.
Bailey, et al., A Concise Dictionary of Plants Cultivated in the United States and Canada. Hortus Third (1976), pp. ix-xiii AND 1098-1099.
Harvey, S.D., et al., Separation of Taxol From Related Taxanes in Taxus Brevifolia Extracts by Isocratic Elution Reversed-Phase Microcolumn High-Performance Liquid Chromatography. Journal of Chromatography (1991) 587: 300-305.
McLaughlin, J.L., et al., 19-Hydroxybaccatin III, 10-Deacetylcephalomannine, and 10-Deacetyltaxol: New Anti-Tumor Taxanes From Taxus Wallichiana. Journal of Natural Products (1981) 44:312-319.
Miller, R.W., A Brief Survey of Taxus Alkaloids and Other Taxane Derivatives. J. Natural Prod. (1980) 43(4): 425-437.
Miller, R.W., et al., Antileukemic Alkaloids From Taxus Wallichiana Zucc. J. Organic Chemistry (1981) 46: 1469-1474.
Rowinsky, E.K., et al., Taxol: A Novel Investigational Antimicrotubule Agent. Journal of the National Cancer Institute (1990) 82(15); 1247-1259.
Senilh, V., et al., Mise En Evidence De Nouveaux Analogues Du Taxol Extraits De Taxus Baccata. Journal of Natural Products (1984) 47: 131-137.
Vanhaelen-Fastre, R., et al., High-Speed Countercurrent Chromatography Separation of Taxol and Related Diterpenoids From Taxus Baccata. Journal of Liquid Chromatography (1992) 15(4): 697-706.
Wani, et al., Plant Antitumor Agents, VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus brevifolia, J. American Chemical Society (1971) 93(9): 2325-2327.
Withrup, K.M., et al., High Performance Liquid Chromatographic Separation of Taxol and Related Compounds From Taxus brevifolia. Joural of Liquid Chromatography (1989) 12(11): 2117-2132.
Witherup, K.M., et al., Taxus Spp. Needles Contain Amounts of Taxol Comparable to the Bark of Taxus Brevifolia: Analysis and Isolation. Journal of Natural Products (1990) 53(5): 1249-1255.
Zongping Zhang, et al., New Taxanes from Taxus Chinensis. Planta Medica (1990) 56: 293-294.
Croom, Jr. Edward M.
ElSohly Hala N.
ElSohly Mahmoud A.
McChesney James D.
Rollins John W.
The University of Mississippi
White John P.
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