Methods and compositions for inhibition of hepatic clearance of

Details Methods and compositions for inhibition of hepatic clearance of Methods and compositions for inhibition of hepatic clearance of

1992-12-18

1995-12-12

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 530350, 530395, 524 2, 524 8, 524 12, A61K 3816, A61K 3849, C07K 1447

Patent

active

054747660

ABSTRACT:
Methods and compositions for inhibiting the hepatic clearance of tissue-type plasminogen activator (t-PA) in vivo by administering a t-PA-hepatic clearance-inhibiting amount of 39 kDa protein or a t-PA-hepatic clearance-inhibiting fragment thereof, or genetically or chemically modified forms of the 39 kDa protein or fragments thereof are described. Methods and compositions for treatment of thrombolytic diseases by administering t-PA and a t-PA-hepatic clearance-inhibiting effective amount of 39 kDa protein, a t-PA-hepatic clearance inhibiting fragment thereof, and genetically or chemically modified forms of the 39 kDa protein or its fragments are described.

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