Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-02-08
2005-02-08
Lankford, Jr., Leon B. (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S018000, C435S019000, C435S023000, C435S024000, C435S200000, C435S226000
Reexamination Certificate
active
06852482
ABSTRACT:
Compositions comprising a novel protease capable of cleaving β-amyloid precursor protein (APP) on the amino-terminal side of the β-amyloid peptide therein are provided. The protease is designated β-secretase. Reaction systems comprising β-secretase may be used in screening assays to monitor β-secretase modulated cleavage of APP and to identify β-secretase inhibitors, wherein the β-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of β-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.
REFERENCES:
patent: 6221645 (2001-04-01), Chrysler et al.
Anderson John P.
Chrysler Susanna M. S.
Keim Pamela S.
McConlogue Lisa Clair
Sinha Sukanto
Elan Pharmaceuticals Inc.
Lankford , Jr. Leon B.
Stratford Carol A.
Townsend and Townsend / and Crew LLP
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