Methods and compositions for inhibiting production of replicatio

Details Methods and compositions for inhibiting production of replicatio Methods and compositions for inhibiting production of replicatio

1994-09-07

1997-12-16

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Canine cell, per se

4353201, 435366, C12N 510, C12N 1586

Patent

active

056984464

ABSTRACT:
The present invention provides methods and compositions for inhibiting the production of replication competent virus. The invention comprises nucleic acid cassettes encoding a non-biologically active inhibitory molecule which are incorporated into packaging cells and recombinant vector constructs. Upon recombination between various vector construct contained within the producer cell, a biologically active molecule is produced which kills the cell, thereby inhibiting production of replication competent virus.

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