Methods and compositions for inhibiting lipoxygenase

Details Methods and compositions for inhibiting lipoxygenase Methods and compositions for inhibiting lipoxygenase

1988-05-20

1989-08-15

Gray, Bruce

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

A61K 3110

Patent

active

048575585

ABSTRACT:
This invention encompasses a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are same or different members of the group consisting of 1,1-dimethyl ethyl, halo, phenyl and substituted phenyl; Alk is straight or branched chain lower alkylene; R.sub.4 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; or a cycloalkyl group of from 3 to 8 carbon atoms. The formulation of this invention are useful as anti-inflammatory and anti-allergy agents.

REFERENCES:
patent: 4029812 (1977-06-01), Wagner et al.
patent: 4108831 (1978-08-01), Cottmann

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