Methods and compositions for inhibiting HIV infection

Details Methods and compositions for inhibiting HIV infection Methods and compositions for inhibiting HIV infection

2006-04-21

2009-10-20

Campell, Bruce (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C536S024500

Reexamination Certificate

active

07604977

ABSTRACT:
This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to modulate a biological activity of isopeptidase T (IsoT), e.g., its isopeptidase activity or its binding to another molecule such as viral protein R (Vpr). Such IsoT modulators can be further examined for their activity in inhibiting an activity indicative of HIV infection or HIV replication. These novel anti-HIV agents are useful in the prevention or treatment of HIV infection and conditions associated with or caused by HIV infection.

REFERENCES:
patent: 2004/0191905 (2004-09-01), Stevenson et al.

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