Methods and compositions for inhibiting enterohepatic cycling of

Details Methods and compositions for inhibiting enterohepatic cycling of Methods and compositions for inhibiting enterohepatic cycling of

1997-08-28

1998-09-08

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514494, A61K 3332, A61K 31315

Patent

active

058042180

ABSTRACT:
Methods and compositions for removing bilirubin from the gastrointestinal tract are described. The compositions contain a zinc salt in a form that is insoluble in the gastrointestinal tract. The methods and compositions are useful for treating patients that have disorders associated with an elevated concentration of bilirubin including, for example, gallstone related disorders.

REFERENCES:
patent: 4548922 (1985-10-01), Carey et al.
patent: 4746508 (1988-05-01), Carey et al.
patent: 4959358 (1990-09-01), Carey et al.
patent: 5589504 (1996-12-01), Dannenberg
Mendez-Sanchez et al., Inhibition of the Enterohepatic Cycling of Unconjugated Bilitubin by Zinc Abstract), 1997.
Gilbertsen, A.S., et al. "Enterohepatic circulation of Unconjugated Bilirubin in Man", Nature, (1962), 196:141-142.
Ulstrom, R.A. and Eisenklam, E., "The Enterohepatic Shunting of Bilirubinin in the Newborn Infant", J. Pediatr, (1964), 65(1):27-37.
Odell, G.B., "`Physiologic`, Hyperbilirubinemia in the Neonatal Period", N Engl J Med, (1967), 277(4): 193-195.
Poland, R.L. and Odell, G.B., "Physiologic Jaundice: The Enterohepatic Circulation of Bilirubin", N Engl J Med. (1971), 284(1):1-6.
Poland, R.L., et al., "High Milk Lipase Activity Associated with Breast Milk Jaundice", Pediatr Res, (1980), 14(12):1328-1331.
Gourley, G.R., et al., "The Effect of Saccharolactone on Rat Intestinal Absorption of Bilirubin in the Presence of Human Breast Milk", Pediatr Res, (1989), 25(3):234-238.
Alonso, E.M., et al., "Enterohepatic Circulation of Nonconjugated Bilirubin in Rats Fed with Human Milk", J Pediatr, (1991), 118(3):425-430.
Gourley, G.R., et al., "The Effect of Diet on Feces and Jaundice During the First 3 Weeks of Life", Gastroenterology, (1992), 103:660-667.
R. Broderson and L.S. Hermann, "Intestinal Reabsorption of Unconjugated Bilirubin", The Lancet, (Jun. 8, 1963) 1242.

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