Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
1998-06-30
Jordan, Charles T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514618, 514619, 564162, 564164, 564165, 564167, 564168, 564170, A01N 3718
Patent
active
057734763
ABSTRACT:
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR.
REFERENCES:
patent: 5217999 (1993-06-01), Levitzki et al.
G. Kaur, A. Gazit, A. Levitzki, E. Stowe, D. Cooney, E. Sausville, Anti-Cancer Drugs 1994, vol. 5, pp. 213-222, Mar. 1994.
Aaronson, S., "Growth Factors and Cancer," Science 254:1146-1153 (1991).
Affleck et al., Proc. Annu. Meeting American Associate Cancer Research 34:A2298 (1993).
Anafi et al., "Selective Interactions of Transforming and Normal abl Proteins with ATP, Tyrosine-Copolymer Substrates, and Tyrphostins," J. Bio. Chem. 267:4518-4523 (1992).
Andrews et al. (American Veterinary Medicine Association Panel on Euthanasia), "1993 Report of the AVMA Panel on Authanasia," J. American Veterinary Medicine Association 202(2):229-249 (1993).
Baselga et al., "Antitumor Effects of Doxorubicin in Combination With Anti-epidermal Growth Factor Receptor Monoclonal Antibodies," J. of Natl. Cancer Institute 85(16):1327-1333 (1993).
Bilder et al., "Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells," Am. J. Physiol. 260 (Cell Physiol.29):C721-C730 (1991).
Birchall et al., "Compositions for killing internal parasites containing 3-teri-alkyl-4-hydroxy-5-halobenzylidene-malononitriles," Chemical Abstracts 88:535 (1978).
Bryckaert et al., "Inhibition of Platelet-Derived Growth Factor-Induced Mitogenesis and Tyrosine Kinase Activity in Cultured Bone Marrow Fibroblasts by Tyrphostins," Exp. Cell Research 199:255-261 (1992).
Caraglia et al., "Cytosine arabinoside increases the binding of .sup.125 I-labelled epidermal growth factor and .sup.125 I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor)mAb," Cancer Immunol. Immunother. 37:150-156 (1993).
Carboni et al., "Cyanocarbon Chemistry. XI. Malononitrile Dimer," J. Am. Chem. Soc. 80:2838-2840 (1958). N-Oxides," J. Org. Chem. 40(24):3608-3610 (1975).
Levitzki, A., "Tyrphostins--Potential Antiproliferative Agents and Novel Molecular Tools," Biochem. Pharm. 40(5):913-918 (1990).
Ley and Seng, "Synthesen unter Verwendung von Benzofuroxan," Synthesis 1975:415-422 (1975).
Lyall et al., "Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-stimulated Cell Proliferation," J. Bio. Chem. 264:14503-14509 (1989).
Marshall, E., "Search for a Killer: Focus Shifts from Fat to Hormones," Science 259:618-621 (1993).
Mosmann, "Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays," J. Immunol. Methods 65:55-63 (1983).
Mitus and Rosenthal, "Ch. 30--Adult Leukemias," Textbook of Clincal Oncology, Holleb, Fink and Murphy eds., pp. 410-432.
Ohmichi et al., "The Tyrosine Kinase Inhibitor Tyrphostin Blocks the Cellular Actions of Nerve Growth Factor," Biochemistry 32:4650-4658 (1993).
O'Rourke and Kalter, "Ch. 28--Leukemia" in Clinical Oncology, Weiss et al. eds, Appleton & Lange, Norwalk Conn., pp. 272-283 (1993).
Osborne et al., "Effect of Estrogens and Antiestrogens on Growth of Human Breast Cancer Cells in Athymic Nude Mice," Cancer Research 45:584-590 (1985).
Osherov et al., "Selective Inhibition of the EGF and Neu receptors by Tyrophostins," J. Cell Biochem. S17A:237 (1993).
Osherov et al., "Selective Inhibition of the Epidermal Growth Factor and HER2/Neu Receptors by Tyrphostins," J. Bio. Chem. 268:11134-11142 (1993).
Ozzello and Sordat, "Behavior of Tumors Produced by Transplantation of Human Mammary Cell Lines in Athymic Nude Mice,"Eur. J. Cancer 16:553-559 (1980).
Pawson and Schlessinger, "SH2 and SH3 domains," Current Biology 3(7):434-441 (1993).
Peterson and Barnes, "Genistein and Biochanin A Inhibit the Growth of Human Prostate Cancer Cells but not Epidermal Growth Factor Receptor Tyrosine Autophosphorylation," The Prostate 22:335-345 (1993).
Pigott et al., "Expression of epidermal growth factor receptor in human glioblastoma multiforme," Brit. J. of Neurosurgery 7:261-265 (1993).
Plowman et al., "Heregulin induces tyrosine phosphorylation of HER4/p180.sup.erbB4," Nature 366:473-475 (1993).
Pui and Rivera, "Ch. 31--Childhood Leukemias," Textbook of Clincal Oncology, Holleb, Fink and Murphy eds., pp. 433-452.
Reddy et al., "Inhibition of Breast Cancer Cell Growth in Vitro by a Tyrosine Kinase Inhibitor," Cancer Research 52:3636-3641 (1992).
Rendu et al., "Inhibition of Platelet Activation by Tyrosine Kinase Inhibitors," Biochem. Pharm. 44(5):881-888 (1992).
Rusch et al., "Differential Expression of the Epidermal Growth Factor Receptor and Its Lgands in Primary Non-Small Cell Lung Cancers and Adjacent Benign Lung," Cancer Research 53:2379-2385 (1993).
Rubens, "Improving Treatment for Advanced Breast Cancer," Cancer Surveys 18:199-209 (1993).
Rygaard and Povlsen, "Heterotransplantation of a Human Malignant Tumour to `Nude` Mice," Acta path. microbiol. scand. 77:758-760 (1969).
Samanta, "Ligand and p185.sup.c-neu density govern receptor interactions and tyrosine kinase activation," Proc. natl. Acad. Sci. USA 91:1711-1715 (1994).
Sammes et al., ".alpha.-Cyano-sulphonyl Chlorides: Their Preparation and Reactions with Amines, Alcohols and Enamines," J. Chem. Soc. pp. 2151-2155 (1971).
Sarup, "Characterization of an Anti-p185.sup.HER2 Monoclonal Antibody that Stimulates Receptor Function and Inhibits Tumor Cell Growth," Growth Regulation 1:72-82 (1991).
Schlessinger, J., "Signal transduction by allosteric receptor oligomerization," Trends Biochem. Sci. 13:443-447 (1988).
Schlessinger and Ullrich, "Growth Factor Signalling by Receptor Tyrosine Kinases," Neuron 9:383-391 (1992).
Schornagel et al., "Synthesis and Evaluation of 2,4-Diaminoquinazoline Antifolates with Activity Against Methotrexate-Resistant Human Tumor Cells," Biochem. Pharm. 33(20):3251-3255 (1984).
Scott et al., "p185.sup.HER2 Signal Transduction in Breast Cancer Cells," J. Bio. Chem. 266(22):14300-14305 (1991).
Seibert et al., "Clonal Variation of MCF-7 Breast Cancer Cells in Vitro and in Athymic Nude Mice," Cancer Research 43:2223-2239 (1983).
Shafie and Grantham, "Role of Hormones in Growth and Regression of Human Breast Cancer Cells (MCF-7) Transplanted into Athymic Nude Mice," J. Natl Cancer Institute 67(1):51-56 (1981).
Shepard, "Monoclonal Antibody Therapy of Human Cancer: taking the HER2 Protooncogene to the Clinic," Journal of Clinical Immunology 11:117-126 (1991).
Skehan et al., "New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening," J. Natl. Cancer Inst. 82:1107-1112 (1990).
Slamon et al., "Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HEr-2
eu Oncogene," Science 235:177-185 (1987).
Sliwkowski et al., "Coexpression of erbB2 and erbB3 Proteins Reconstitutes a High Affinity Receptor for Heregulin," J. Biol. Chem. 269:14661-14665 (1994).
Stein et al., "The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer," EMBO Journal 13(6):1331-1340 (1994).
Ullrich and Schlessinger, "Signal Transduction by Receptors with Tyrosine Kinase Activity," Cell 61:203-212 (1990).
Wada et al., "Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins," Oncogene 5:489-495 (1990).
Wada, "Intermolecular Association of the p185.sup.neu Protein and EGF Receptor Modulates EGF Receptor Function," Cell 61:1339-1347 (1990).
Warri et al., "Estrogen Suppression of erbB2 Expression is Associated with Increased Growth Rate of ZR-75-I Human Breast Cancer Cells In Vitro and in Nude Mice," Int. J. Cancer 49:616-623 (1991).
Yaish et al., "Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors," Science 242:933-935 (1988).
Yarden, "Growth factor receptor tyrosine kinase," Ann. Rev. Biochem. 57:443-478 (1988).
Yoneda et al., "The Antiproliferative Effects of Tyrosine Kinase Inhibitors Tyrphostins on a Hum
Chen Hui
Gazit Aviv
Hirth Klaus Peter
Levitzki Alexander
Mann Elaina
Hardee John R.
Jordan Charles T.
Sugen Inc.
Yissum Research and Development Company of the Hebrew University
LandOfFree
Methods and compositions for inhibiting cell proliferative disor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for inhibiting cell proliferative disor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for inhibiting cell proliferative disor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1859850