Methods and compositions for inhibiting angiogenesis

Details Methods and compositions for inhibiting angiogenesis Methods and compositions for inhibiting angiogenesis

2006-09-12

2006-09-12

Qian, Celine (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C435S325000

Reexamination Certificate

active

07105496

ABSTRACT:
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

REFERENCES:
patent: 4160452 (1979-07-01), Theeuwes
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen
patent: 4980286 (1990-12-01), Morgan et al.
patent: 4996159 (1991-02-01), Glaser
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5424398 (1995-06-01), Middeldorp et al.
patent: 6288024 (2001-09-01), Bouck et al.
patent: 6670333 (2003-12-01), Bouck et al.
patent: WO 93/24529 (1993-12-01), None
patent: WO 95/33480 (1995-12-01), None
Adamis, et al., 1994, Am. J. Ophthalmol. 118:445.
Adamis, et al., 1996, Arch. Ophthalmol. 114:66.
Aiello, et al., 1994, N. Engl. J. Med.331:1480.
Stellmach, V., et al., 2001, PNAS, vol. 98 No. 5 2593-2597.
Aiello, et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:10457.
Altschul, et al., 1997, Nucleic Acids Res. 25:3389-3402.
Bain, et al., 1994, Gene Therapy 1:S68.
Barany, et al, 1987, Int. J. Peptide Protein Res. 30:705-739.
Becerra, et al., 1993, J. Biol. Chem. 268:23148-23156.
Becerra, et al., 1995, J. of BIol. Chemistry 270:25992-25999.
Becerra, Chemistry and Biology of Serpins, Church, et al., Eds. (Plenum, New York, 1997), pp. 223-237.
Berns and Giraud, 1995, Ann. N.Y. Acad. Sci. 772:95-104.
Bouck, et al., 1996, Adv. Cancer 69:135-174.
Connolly, et al., 1988, Microvas. Res. 36:275-290.
DiPaolo, et al., 1995, Exp. Cell Res. 220:178-185.
Federoff, et al., 1992, Proc. Natl. Acad. Sci. USA 89:1636-1640.
Fink, et al., 1996, Ann. Rev. Neurosci. 19:265-287.
Folkman and Klagsbrun, 1987, Science 235:442-447.
Folkman and Shing, 1992, J. Biol. Chem. 267(16):10931-10934.
Folkman, et al., 1995, Molecular Basis of Cancer 206-232.
Folkman, 1986, J. Cancer Res. 46:467-473.
Folkman, 1989, J. Natl. Cancer Inst. 82:4-6.
Gasparini, 1996, Eur. J. Cancer 32A(14):2379-2385.
Goldberg, et al., 1988, Science 242:1412-1415.
Gulledge and Dewhirst, 1996, Anticancer Res. 16:741-749.
Hanahan and Folkman, 1996, Cell 86:353-364.
Hayasaka, et al., 1998, Life Sci. 63:1089-1096.
Kaminska and Niederkorn, 1993, Investig. Opthalmol. Vis. Sci. 34:222-230.
O'Reilly, et al., 1994, Cell 79:315-328.
O'Reilly, et al., 1997, Cell 88:277-285.
Ogata, et al., 1997, Curr. Eye Res. 16:9-18.
Pierce, et al., 1996, Arch. Ophthalmol. 114:1219-1228.
Pignolo, et al., 1993, J. Biol. Chem. 268:8949-8957.
Polverini, et al., 1991, Methods in Enzymology 198:440-450.
Polverini, et al., 1991, Methods in Enzymology 194:440.
Provis, et al., 1997, Exp. Eye Res. 65:555-568.
Smith, et al., 1994, Invest. Ophthalmol. Vis. Sci. 35:101-111.
Steele, et al., 1993, Proc. Natl. Acad. Sci. USA 90(4):1526-1530.
Sugita, et al., 1997, J. Neurosci. Res. 49:710-718.
Tanawaki, et al., 1995, J. Neurochem. 64:2509-2517.
Teicher, et al., 1994, Int. J. Cancer 57:920-925.
Tombran-Tink, et al., 1991, Exp. Eye Res. 53:411-414.
Tombran-Tink, et al., 1995, J. Neurosci., 15:4992-5003.
Vinores, et al, 1998, J. Neuroimmunol. 89:43-50.
Weidner 1991, New Eng. J. Med. 324(1):1-8.
Wu and Beccera, 1996, Investig. Ophthalmol. Vis. Sci. 37:1984-1993.
Xu, et al., 1991, Cancer Res. 51:4481-4485.

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