Methods and compositions for inhibiting angiogenesis

Details Methods and compositions for inhibiting angiogenesis Methods and compositions for inhibiting angiogenesis

2005-07-19

2005-07-19

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S021800, C424S574000, C424S537000, C424S571000

Reexamination Certificate

active

06919309

ABSTRACT:
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

REFERENCES:
patent: 4160452 (1979-07-01), Theeuwes
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen
patent: 4996159 (1991-02-01), Glaser
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5424398 (1995-06-01), Middeldorp et al.
patent: 6288024 (2001-09-01), Bouck et al.
patent: WO 93/24529 (1993-12-01), None
patent: WO 95/33480 (1995-12-01), None
Adamis, et al., 1994, Am. J. Ophthalmol. 118:445.
Adamis, et al., 1996, Arch. Ophthalmol. 114:66.
Aiello, et al., 1994. N. Engl. J. Med. 331:1480.
Aiello, et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:10457.
Altschul, et al., 1997, Nucleic Acids Res. 25:3389-3402.
Bain, et al., 1994, Gene Therapy 1:S68.
Barany, et al., 1987, Int. J. Peptide Protein Res. 30:705-739.
Becerra, et al., 1993, J. Biol. Chem. 268:23148-23156.
Becerra, et al., 1995, J. of Biol. Chemistry 270:25992-25999.
Becerra Chemistry and Biology of Serpins, Church, et al., Eds. (Plenum, New York, 1997), pp 223-237.
Berns and Giraud, 1995, Ann. N.Y. Acad. Sci. 772:95-104.
Bouck, et al., 1996, Adv. Cancer 69:135.
Connolly et al., 1988, Microvas. Res. 36:275.
Dipaolo, et al., 1995, Exp. Cell Res. 220:178-185.
Federoff, et al., 1992, Proc. Natl. Acad. Sci. USA 89:1636-1640.
Fink, et al., 1996, Ann. Rev. Neurosci. 19:265-287.
Folkman and Klagsbrun, 1987, Science 235:442-447.
Folkman and Shing, 1989, J. Biol. Chem. 267(16):10931-10934.
Folkman, et al., 1995, Molecular Basis of Cancer 206-232.
Folkman, 1986, J. Cancer Res. 46:467-473.
Folkman, 1989, J. Nat. Cancer Inst. 82:4-6.
Gasparini, 1996, Eur. J. Cancer 32A(14):2379-2385.
Goldberg, et al., 1988, Science 242:1214.
Gulledge and Dewhirst, 1996, Anticancer Res. 16:741.
Hanahan and Folkman, 1996, Cell 86:353.
Hayasaka, et al., 1998, Life Sci. 63:1089.
Kaminska and Niederkorn, 1993, Investig. Ophthalmol. Vis. Sci. 34:222.
O'Reilly, et al., 1994, Cell 79:315-328.
O'Reilly, et al., 1997, Cell 88:277-285.
Ogata, et al., 1997, Curr. Eye Res. 16:9.
Pierce, et al., 1996, Arch. Ophthalmol. 114:1219.
Pignolo, et al., 1993, J. Biol. Chem. 268:8949.
Polverini, et al., 1991, Methods in Enzymology 198:440-450.
Polverini, et al., 1991 Methods Enzymol 194:440.
Provis, et al., 1997, Exp. Eye Res. 65:555.
Smith, et al., 1995, Invest. Ophthalmol. Vis. Sci. 35:101.
Steele, et al., 1993, Proc. Natl. Acad. Sci. USA 90(4):1526-1530.
Sugita, et al., 1997, J. Neurosci. Res. 49:710-718.
Tanawaki, et al., 1995, J. Neurochem. 64:2509-2517.
Teicher, et al., 1994, Int. J. Cancer 57:920-925.
Tombran-Tink, et al., 1991, Exp. Eye Res. 53:411-414.
Tombran-Tink, et al., 1995, J. Neurosci., 15:4992-5003.
Vinores, et al., 1998, J. Neuroimmunol. 89:43.
Weidner, 1991, New Eng. Med. 324(1):1-8.
Wu and Beccerra, 1996, Investig. Ophthalmol. Vis. Sci. 37:1984-1993.
Xu et al., 1991, Cancer Res. 51:4481-4485.

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