Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-10-01
2000-07-11
Elliott, George C.
Chemistry: molecular biology and microbiology
Vector, per se
435 6, 435 914, 435325, 536 231, C12N 1563, C12N 1511, C12Q 168
Patent
active
060871644
ABSTRACT:
The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
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Hu et al. Genomic deletion of an imprint maintenance element abolishes imprinting of both insulin-like growth factor II and H19., JBC, vol. 272, No. 33, pp. 20715-20720, Aug. 1997.
Ayesh Suhail
Hochberg Abraham
Elliott George C.
Epps Janet
Yissum Research Development Company of the Hebrew University of
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